Circadian Pharmacokinetics

Häftad, Engelska, 2021

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This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Produktinformation

Utgivningsdatum2021-10-29
Mått155 x 235 x undefined mm
FormatHäftad
SpråkEngelska
Antal sidor253
FörlagSpringer Verlag, Singapore
ISBN9789811588099

Tillhör följande kategorier

Apotek och farmaceuter inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Farmakologi inom Medicin

Dr. Baojian Wu is a professor at the College of Pharmacy, Jinan University, China. He obtained his Ph.D. from University of Houston in 2011 and completed his post-doctoral training at the Baylor College of Medicine from 2011 to 2012. His research focuses on circadian regulation of drug metabolism and transport, as well as circadian regulation of inflammatory and metabolic diseases, fields in which he has published more than 100 research articles.Dr. Danyi Lu is an associate professor at the College of Pharmacy, Jinan University, China.Dr. Dong Dong is an associate professor at the College of Medicine, Jinan University, China..

Chapter 1. Introduction to mammalian circadian clock system.- Chapter 2. Introduction to pharmacokinetics.- Chapter 3. Circadian clock and metabolic diseases.- Chapter 4. Circadian clock and CYP metabolism.- Chapter 5. Circadian clock and non-CYP phase I metabolism.- Chapter 6. Circadian clock and phase II metabolism.- Chapter 7. Circadian clock and uptake transporters.- Chapter 8. Circadian clock and efflux transporters.- Chapter 9. Role of pharmacokinetics in chronotherapeutics.- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.