Chronic Obstructive Pulmonary Disease

Professor Robert Stockley is the Head of Department at the Queen Elizabeth Hospital in Birmingham. He is a respiratory physician working in the field of chronic obstructive pulmonary disease.Professor Stephen Rennard is Larson Professor of Medicine in the Pulmonary and Critical Care Medicine Section of the Department of Internal Medicine at the University of Nebraska Medical Center in Omaha, Nebraska. He is the North American Editor for Respiratory Medicine and Associate Editor for COPD for the European Respiratory Journal.Professor Klaus Rabe is Professor of Pulmonary Medicine and Chairman for the Department of Pneumology in the University of Leiden. He has been active in various fields of respiratory medicine in Europe and was the first European Associate Editor of the American Journal of Respiratory and Critical Care Medicine. He is co-Chief Editor of the European Respiratory Journal.Dr Bart Celli is Professor of Medicine at Tufts University in Boston and Chief of the Division of Pulmonary and Critical Care Medicine at the St Elizabeth's Medical Center at Tufts University School of Medicine. He is the author of more than 120 publications on COPD and is the co-editor of Baum's Textbook of Pulmonary Diseases and Hodgkin's Textbook in Pulmonary Rehabilitation.

• Contributors. Preface.Section 1: Physiology.1. Structure–Function Relationships: the Pathophysiology of Airflow Obstruction (Dennis E. Niewoehner).2. The Physiology of Breathlessness (Donald A. Mahler).3. The Physiology of Muscle (Ghislaine Gayan-Ramirez and Marc Decramer).4. Exercise Limitations and Cardiopulmonary Exercise Testing in COPD (Norman R. Morris, Lewis Adams, Bruce D. Johnson and Idelle M. Weisman).5. Clinical Assessment of Control of Breathing (Joseph Milic-Emili and Antonia Koutsoukou).6. Physiology and Pathobiology of the Lung Circulation (Norbert F. Voelkel).7. Sleep in Patients with COPD (Mark W. Elliott).8. The Physiology of Cough (Marian Kollarik and Bradley J. Undem).9. The Physiology of Gas Exchange (Robert Rodriguez-Roisin, Andrés Echazarreta, Federico P. Gómez and Joan Albert Barberà).Section 2: COPD and Allied Conditions.10. The Natural History of COPD (Jørgen Vestbo).1.1 Cystic Fibrosis (Marcus P. Kennedy and Michael R. Knowles).12. Bronchiectasis and COPD (Robert Wilson).13. Obliterative Bronchiolitis (Hélène Levrey Hadden and Marshall I. Hertz).14. Asthma (Diana C. Grootendorst and Klaus F. Rabe).15. COPD: Clinical Presentation and Evaluation (Bartolome R. Celli).16. Monitoring and Outcomes (Paul W. Jones).Section 3: Host Defences and Inflammation.17. Mucociliary Clearance (Souheil El-Chemaly, Adam Wanner and Matthias Salathe).18. Mucosal Immunity (Hugues Chanteux, Charles Pilette and Yves Sibille).19. COPD and Pulmonary Surfactant (Carola Seifart and Bernd Muller).20. The Macrophage and its Role in the Pathogenesis of COPD (Kellie R. Jones and Jordan P. Metcalf).21. Eosinophils and COPD (Andrew J. Wardlaw).22. Airway Epithelial Defence, Repair and Regeneration (Christelle Coraux, Jean-Marie Tournier, Jean-Marie Zahm and Edith Puchelle).23. The Role of the Neutrophil in the Pathogenesis of COPD (Ian S. Woolhouse and Robert A. Stockley).24. Lymphocytes (Simonetta Baraldo, Maria Elena Zanin, Renzo Zuin and Marina Saetta).25. Cytokines (Jack A. Elias and Robert J. Homer).26. Leukotrienes in COPD: The Unexploited Potential (Sven-Erik Dahlén).27. Cigarette Smoking, Emphysema and Lung Endothelium (Stephanie A. Nonas, Irina Petrache and Joe G.N. Garcia).28. Mesenchymal Cells of the Lung (Stephen I. Rennard and J. Graham Sharp).Section 4: Pathogenesis.29. Lung Development (Cheng Chen, David Warburton and Wei Shi).30. Animal Models (Piero A. Martorana, Monica Lucattelli, Barbara Bartalesi and Giuseppe Lungarella).31. Proteinases and COPD (Anita L. Sullivan and Robert A. Stockley).32. Oxidants (William MacNee).33. Cigarette Smoke-Induced Disease (Stephen I. Rennard and Lisa M. Hepp).34. COPD and Air Pollution (Kenneth Donaldson, Andrew Churg and William MacNee).35. Viruses in COPD (Sam Hibbitts and Colin Gelder).36. Bacteria (Sanjay Sethi).37. Genetic Factors (Craig P. Hersh and Edwin K. Silverman).38. α1-Antitrypsin Deficiency (Loutfi S. Aboussouan and James K. Stoller).39. Body Weight and Systemic Effects (Emile F.M. Wouters).40. Lung Connective Tissue (Sarah E. Dunsmore and Geoffrey J. Laurent).Section 5: Clinical Considerations and Complications.41. Aerosols and Delivery Systems (Stephen P. Newman).42. Gastro-oesophageal Reflux (John K. DiBaise).43. Upper Airway Diseases (Maria Rappai and Richard deShazo).44. Acute Pulmonary Embolism (Victor F. Tapson).45. COPD and Lung Cancer (Stephen G. Spiro and Frank McCaughan).46. Infection Management and Airflow Obstruction (Alan M. Fein, Jill P. Karpel and Antonio Anzueto).47. Mechanical Ventilation for Exacerbation of COPD (Andrea Rossi, Guido Polese and Lorenzo Appendini).48. Comorbidity (Martin Sevenoaks and Robert A. Stockley).Section 6: Current and Future Treatment.49. Primary Care (Daryl Freeman and David Price).50. Pulmonary Rehabilitation (Richard ZuWallack).51. Social Support (Robin Stevenson).52. Long-Term Invasive Mechanical Ventilation (Gerard J. Criner).53. Smoking Cessation (Philip Tønnesen).54. Oxygen Therapy in COPD (Brian Tiep and Rick Carter).55. Surgical Therapy for COPD (Fernando J. Martinez).56. Anticholinergics in COPD (Theodore J. Witek, Jr).57. β2-Agonists (Malcolm Johnson).58. Corticosteroids (Olof Selroos).59. Phosphodiesterase 4 Inhibitors in the Treatment of COPD (Hermann Tenor, Daniela S. Bundschuh, Christian Schudt, Dirk Bredenbröker and Armin Hatzelmann).60. Antibiotic Therapy in Patients with COPD (Michael S. Niederman).61. Antioxidants (Claudio F. Donner).62. Mucolytics for COPD (Duncan F. Rogers and Bruce K. Rubin).63. End-of-Life and Palliative Care for Patients with COPD (John E. Heffner and Ann L. Heffner).64. Economic Burden of COPD (David H. Au and Sean D. Sullivan).65. Pharmacoepidemiology of COPD (Joan B. Soriano).66. Social and Behavioural Impact of COPD – Research Opportunities (Suzanne S. Hurd and Claude Lenfant).67. Guidelines (Peter M.A. Calverley).Section 7: Pharmacotherapy: Developing Therapies.68. Protease Inhibitors (Philip Davies, Malcolm MacCoss and Richard Mumford).69. Retinoids (Stephen R. Tudhope).70. Chemokines in COPD (Peter J. Barnes).Index.

"Appropriate to the intense proliferation of research and publications in the last few decades for this major health problem, the editors of Chronic Obstructive Pulmonary Disease have produced a comprehensive textbook that spans the basic and clinical science of COPD. This substantial tome includes 912 pages, 243 illustrations, and 70 chapters authored by an international cadre of contributors... The succinct writing style, judicious use of complementary illustrations, and well-focused references achieve the desired breadth without compromising sufficient depth or readability... Section 3 focuses on cellular physiology and inflammation. This section exemplifies the strength of this textbook, digesting a large body of developing science into comprehensible synopses of the disease processes that form the basis for therapeutic opportunities... In summary, the editors and authors of Chronic Obstructive Pulmonary Disease have achieved their goal by creating a current textbook covering many facets of this complex disorder. In parallel with the field of COPD, the textbook has its strength in the scientific underpinnings of airway and lung physiology and advances in the understanding of cellular and physiological derangements." - Richard A. Mularski (MD, MSHS, MRC), JAMA, September 2007 “The strength of the book lies in the more than 100 authors…recognized worldwide. Most of the chapters are excellent reviews and are carefully referenced.”New England Journal of Medicine "...In summary, the editors and authors of Chronic Obstructive Pulmonary Disease have achieved their goal by creating a current textbook covering many facets of this complex disorder. In parallel with the field of COPD, the textbook has its strength in the scientific underpinnings of airway and lung physiology and advances in the understanding of cellular and physiological derangements"Richard A. Mularski for John L. Zeller, MD, PhD, Fishbein Fellow Books and Media Reviews Section Editor, JAMA “This book does an outstanding job of outlining the major aspects of COPD. Topics are organized logically and each chapter has ample references…highlighting important concepts."Doodys Reviews