Chronic Inflammation

Masayuki Miyasaka, MD, PhDSpecially-Appointed Professor, IPBS, Osaka University,Professor Emeritus, Osaka University,FiDiPro Professor, Academy of Finland,JST-CREST “Chronic Inflammation” Research Supervisor Kiyoshi Takatsu, PhDDirector, Toyama Prefectural Institute for Pharmaceutical Research,Visiting Professor, University of Toyama,Professor Emeritus, The University of Tokyo, JST-PRESTO “Chronic Inflammation” Research Supervisor

• Part 1. Basic mechanisms underlying induction, progression, and resolution of chronic inflammation.- 1 Prostaglandins in chronic inflammation.- 2 Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis.- 3 Sema4A and chronic inflammation.- 4 MicroRNAs in Chronic Inflammation Diseases.- 5 Genetic dissection of autoinflammatory syndrome.- 6 Structural biology of chronic inflammation-associated signaling pathways: toward structure-guided drug development.- 7 Lipid signals in the resolution of inflammation.- 8 Regulation of chronic inflammation by control of macrophage activation and polarization.- 9 Clarification of the molecular mechanisms that negatively regulate inflammatory responses.- 10 The Drosophila Toll pathway: a model of innate immune signaling activated by endogenous ligands.- Part 2. Imaging analyses of chronic inflammation.- 11 Macrophage dynamics during bone resorption and chronic inflammation.- 12 Development of imaging mass spectrometry techniques for visualizing localized cellular signaling mediators in tissues.- 13 Tracking of follicular T cell dynamics during immune responses and inflammation.- Part 3. Chronic inflammation and cancer.- 14 The role of chronic inflammation in the promotion of gastric tumorigenesis.- 15 Cellular senescence as a novel mechanism of chronic inflammation and cancer progression.- 16 Establishment of diagnosis for early metastasis.- 17 Non-autonomous tumor progression by oncogenic inflammation.- 18 Inflammation-associated carcinogenesis mediated by the impairment of microRNA function in the gastroenterological organs.- 19 Roles of Epstein–Barr virus micro RNAs in Epstein–Barr virus-associated malignancies.- Part 4. Chronic inflammation and obesity/environmental stress.- 20 Chronicity of immune abnormality in atopic dermatitis: Interacting surface between environment and immune system.- 21 Role of double-stranded RNA pathways in immunometabolism in obesity.- 22 Molecular mechanisms underlying obesity-induced chronic inflammation.- 23 Roles of mitochondrial sensing and stress response in the regulation of inflammation.- 24 Oxidative stress regulation by reactive cysteine persulfides in inflammation.- Part 5. Chronic inflammation and innate immunity.- 25 Post-transcriptional Regulation of Cytokine mRNA Controls the Initiation and Resolution of Inflammation.- 26 Roles of C-type Lectin Receptors in Inflammatory Responses.- 27 Elucidation and control of the mechanisms underlying chronic inflammation mediated by invariant natural killer T cells.- 28 Understanding of the role of plasmacytoid dendritic cells in the control of inflammation and T-cell immunity.- 29 Mechanisms of lysosomal exocytosis by immune cells.- 30 Potential Therapeutic Natural Products for the Treatment of Obesity-associated Chronic Inflammation by Targeting TLRs and Inflammasomes.- Part 6. Chronic inflammation and adaptive immunity.- 31 Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation.- 32 Controlling the mechanism underlying chronic inflammation through the epigenetic modulation of CD4 T cell senescence.- 33 Adrenergic control of lymphocyte dynamics and inflammation.- 34 The multifaceted role of PD-1 in health and Disease.- 35 The role of lysophospholipids in immune cell trafficking and inflammation.- Part 7. Chronic inflammation and autoimmune diseases.- 36 Devising novel methods to control chronic inflammation via regulatory T cells.- 37 Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms.- 38 Lysophosphatidylserine as an inflammatory mediator.- 39 Aberrant activation of RIG-I like receptors and autoimmune diseases.- 40 Elucidation of the exacerbation mechanism of autoimmune diseases caused by disruption of the ion homeostasis.- Part 8. Chronic inflammation and aging.- 41 Pathophysiological role of chronic inflammation in aging-associated diseases.- 42 Uterine cellular senescence in the mouse model of preterm birth.- Part 9. Chronic inflammation and bowel diseases.- 43 Physiological and Pathological Inflammation at the Mucosal Frontline.- 44 Control of intestinal regulatory T cells by human commensal bacteria.- 45 Roles of the epithelial autophagy in the intestinal mucosal barrier.- 46 Development of sentinel-cell targeted therapy for inflammatory bowel diseases.- 47 Identification of long non-coding RNAs involved in chronic inflammation in Helicobacter pylori infection and associated gastric carcinogenesis.- Part 10. Chronic inflammation and central nervous system disease.- 48 The research for the mechanism of chronically intractable pain based on the functions of microglia as brain immunocompetent cell.- 49 The role of innate immunity in ischemic stroke.- 50 Chronic neuroinflammation underlying pathogenesis of Alzheimer's disease.- Part 11. Chronic inflammation and cardiovascular diseases.- 51 The roles of hypoxic responses during the pathogenesis of cardiovascular diseases.- 52 Preventionand treatment of heart failure based on the control of inflammation.