Chromosomes

The Complex Code

Inbunden, Engelska, 1996

AvM. Clark,W. Wall

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This text presents a concise account of modern cytogenetics. Basic facts are presented together with illustrative examples from plant, animal and medical cytogenetics. Selected references guide the reader to recent literature. The book emphasizes the revitalization of cytogenetics resulting from research into the human genome and the subject's integration with molecular biology. Classic cytogenetics is also discussed to give context to more recent studies. This book should be of interest to geneticists, cell biologists, molecular biologists, and students on undergraduate courses in a range of disciplines, medical and life science courses.

Produktinformation

Utgivningsdatum1996-06-30
Mått210 x 297 x 24 mm
Vikt972 g
FormatInbunden
SpråkEngelska
Antal sidor346
Upplaga1996
FörlagChapman and Hall
ISBN9780412752100

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Medicinsk genetik inom Medicin
Djurböcker inom Djur och natur
Zoologi inom Naturvetenskap och teknik

1 Chromatin structure and replication.- 1.1 Chromosome structure.- 1.2 Evidence that DNA is the genetic material.- 1.3 The double helix.- 1.4 The genetic code.- 1.5 DNA constitution.- 1.6 Higher order structure of DNA.- 1.7 Chromosome replication.- 2 Chromosome form and function.- 2.1 Structures in a chromosome.- 2.2 Heterochromatin.- 2.3 Telomeres.- 2.4 Centromeres and kinetochores.- 2.5 Nucleolar organizing regions.- 2.6 Lampbrush and polytene chromosomes.- 2.7 Double minutes and homogeneously staining regions.- 2.8 B chromosomes.- 2.9 Supernumerary segments.- 2.10 Artificial chromosomes.- 3 Chromosome identification.- 3.1 The karyotype.- 3.2 Chromosome banding.- 4 Nuclear division.- 4.1 Mitosis.- 4.2 The spindle apparatus.- 4.3 Meiosis.- 4.4 Chromosome pairing.- 4.5 Synaptonemal complex formation.- 4.6 Recombination nodules.- 4.7 Recombination and gene conversion.- 4.8 Meiosis in polyploids and structural rearrangements.- 4.9 Structural changes.- 5 Gene control by position and origin.- 5.1 Chromosome organization within the nucleus.- 5.2 Chromosomal imprinting.- 6 Mutagenesis.- 6.1 General ideas about mutagenesis.- 6.2 Changes associated with the environment.- 6.3 Chromosomal aberrations.- 6.4 Aneuploidies.- 6.5 Mutations affecting cell proliferation.- 6.6 Translocations.- 6.7 Fragile sites.- 6.8 Transposable elements.- 7 Chromosome mapping.- 7.1 Introduction.- 7.2 Genetic maps.- 7.3 Cytological maps.- 7.4 Correlation between genetic and cytological/physical maps.- 7.5 Mapping strategies.- 8 Sex chromosome systems.- 8.1 Heteromorphic sex chromosome systems.- 8.2 Mammalian sex chromosome systems.- 8.3 X inactivation.- 8.4 Mammalian sex chromosome evolution.- 8.5 Other sex chromosome systems.- 9 Evolution and speciation.- 9.1 Hybrids and cultivars.- 9.2 Speciation by karyotype changes.- 9.3 Speciation in an ancient mammalian group.- 9.4 Evolution of the hominids.- 10 Artificial manipulation of genomes.- 10.1 Manipulation of whole chromosome sets.- 10.2 Manipulationof single chromosomes.- 10.3 Manipulation producing variable genome changes.- 10.4 Single-gene transfer.- 11 Historical aspects of cytogenetics.