Chiral Drugs

GUO-QIANG LIN, is a professor at the Shanghai Institute of Organic Chemistry and an adjunct professor at Fudan University, China. He is the Director of the Division of Chemical Science of the National Natural Science Foundation of China. Among Professor Lin's publications are the Wiley books Principles and Applications of Asymmetric Synthesis and Biocatalysis for the Pharmaceutical Industry. QI-DONG YOU, PHD, is the Dean and a professor of the School of Pharmacy at China Pharmaceutical University. He is an Associate Editor of Progress in Pharmaceutical Sciences and serves on the Editorial Board of the International Journal of Medicinal Chemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor of over eighty publications, and an inventor or co-inventor of over twenty patent applications and patents.JIE-FEI CHENG, PHD, is the Director of Otsuka Shanghai Research Institute, a fully owned subsidiary of Otsuka Pharmaceutical Co., Ltd Japan. Formerly an associate professor at Shanghai Institute of Organic Chemistry, he has worked for over fifteen years in the pharmaceutical and biotech industries in the United States. Dr. Cheng is a coauthor of over fifty peer-reviewed publications, and an inventor or coinventor of over twenty patent applications and patents.

• ABOUT THE EDITORS vii CONTRIBUTORS ixINTRODUCTION 11 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29Guo-Qiang Lin and Xing-Wen Sun3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77Jianqiang Wang and Wenya Lu4 RESOLUTION OF CHIRAL DRUGS 137Qi-Dong You5 FLUORINE-CONTAINING CHIRAL DRUGS 195Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297Deping Wang and Eric Hu8 PHARMACOLOGY OF CHIRAL DRUGS 323Yongge Liu and Xiao-Hui Gu9 PHARMACOKINETICS OF CHIRAL DRUGS 347Hanqing Dong, Xiaochuan Guo and Zengbiao Li10 TOXICOLOGY OF CHIRAL DRUGS 381Guang Yang and Hai-Zhi Bu11 REPRESENTATIVE CHIRAL DRUGS 401Jiangqin Sun, Dingguo Liu, and Zhimin WangINDEX 449

“The book can be recommended to all those who are interested in this important and fast-growing field of research at the interface of chemistry, pharmacy, and medicine of the basic concepts behind modern biological psychiatric research and the recent history of the field.”  (ChemMedChem, 2012)