Ching-Hon Pui is Chair of the Department of Oncology, Fahad Nassar Al-Rashid Chair of Leukemia Research and co-Director of the Hematological Malignancies Program at St Jude's Children's Research Hospital, Memphis, TN, USA.

• Preface; Part I. History and General Issues: 1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology and Pathobiology: 4. Immunophenotyping Fred G. Behm; 5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 6. Cytogenetics of acute leukemias Susana C. Raimondi; 7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; 8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing; 9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero; 10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters; 11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans; 13. Acute lymphoblastic leukemia Ching-Hon Pui; 14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu; 16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; 17. Relapsed acute myeloid leukemia Ursula Creutzig; 18. Myelodysplastic syndromes Henrik Hasle; 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock; 21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman; 22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher; 23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; 24. Antibody-targeted therapy Alan S. Wayne; 25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop; 26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner; 27. Development therapeutics Sima Jeha; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious complications Hana Hakim and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Doralina L. Anghelescu and Roland Kaddoum; 35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull; 36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard; Index.

Review of the previous editions: '… comprehensively referenced and the indexing is simple to use … informative and relevant … I would commend the book to anyone looking for an up-to-date and comprehensive reference monograph on childhood leukaemia.' The Bulletin of The Royal College of Pathologists

Ching-Hon Pui is Chair of the Department of Oncology, Fahad Nassar Al-Rashid Chair of Leukemia Research and co-Director of the Hematological Malignancies Program at St Jude's Children's Research Hospital, Memphis, TN, USA.

• Preface; Part I. History and General Issues: 1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology and Pathobiology: 4. Immunophenotyping Fred G. Behm; 5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 6. Cytogenetics of acute leukemias Susana C. Raimondi; 7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; 8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing; 9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero; 10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters; 11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans; 13. Acute lymphoblastic leukemia Ching-Hon Pui; 14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu; 16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; 17. Relapsed acute myeloid leukemia Ursula Creutzig; 18. Myelodysplastic syndromes Henrik Hasle; 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock; 21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman; 22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher; 23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; 24. Antibody-targeted therapy Alan S. Wayne; 25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop; 26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner; 27. Development therapeutics Sima Jeha; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious complications Hana Hakim and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Doralina L. Anghelescu and Roland Kaddoum; 35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull; 36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard; Index.

Review of the previous editions: '… comprehensively referenced and the indexing is simple to use … informative and relevant … I would commend the book to anyone looking for an up-to-date and comprehensive reference monograph on childhood leukaemia.' The Bulletin of The Royal College of Pathologists

Ching-Hon Pui is Chair of the Department of Oncology, Fahad Nassar Al-Rashid Chair of Leukemia Research and co-Director of the Hematological Malignancies Program at St Jude's Children's Research Hospital, Memphis, TN, USA.

• Preface; Part I. History and General Issues: 1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology and Pathobiology: 4. Immunophenotyping Fred G. Behm; 5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 6. Cytogenetics of acute leukemias Susana C. Raimondi; 7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; 8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing; 9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero; 10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters; 11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans; 13. Acute lymphoblastic leukemia Ching-Hon Pui; 14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu; 16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; 17. Relapsed acute myeloid leukemia Ursula Creutzig; 18. Myelodysplastic syndromes Henrik Hasle; 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock; 21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman; 22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher; 23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; 24. Antibody-targeted therapy Alan S. Wayne; 25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop; 26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner; 27. Development therapeutics Sima Jeha; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious complications Hana Hakim and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Doralina L. Anghelescu and Roland Kaddoum; 35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull; 36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard; Index.

Review of the previous editions: '… comprehensively referenced and the indexing is simple to use … informative and relevant … I would commend the book to anyone looking for an up-to-date and comprehensive reference monograph on childhood leukaemia.' The Bulletin of The Royal College of Pathologists