Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

Goutam Brahmachari, Ph.D. is an Associate Professor within the Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, at Visva-Bharati University, India.

• Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds. Impact of Solid-Supported Cyclization–Elimination Strategies toward the Development of Natural Product Inspired Molecules in Drug Discovery Research. Synthesis and Biological Studies of Novel β-Lactams. Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry. Role of Organic Carbamates in Anticancer Drug Design. Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials. Synthesis and Biological Activity of Promising Azole Marine Products: Largazole and Neopeltolide. Omega-3 (ω-3) Polyunsaturated Fatty Acids. Structure and Biological Activity of Natural Melanin Pigments. Recent Acquisitions on Naturally Occurring Oxyprenylated Secondary Plant Metabolites. Role of Curcumin in Ameliorating Neuroinflammation and Neurodegeneration Associated with Alzheimer’s Disease. Plant Metabolites. X-Ray Structural Behavior of Some Significant Bioactive Steroids and Their Chemistry in the Crystal Packing and Related Matters. Three-Dimensional Structure of Xanthones. Gambogic Acid. Neuroplasticity as a New Approach to the Pathophysiology of Depression and the Role of Antidepressants in Inhibiting Brain Stress-Induced Changes. Statins. Molecular Aspects of Fungal Bioactive Polyketides. Marine Microalgal Metabolites. Rosmarinic Acid. Enhancement of Natural Antioxidants in Plants by Biosynthetic Pathway Modulation. Plant as Biofactories of Pharmaceuticals and Nutraceuticals.

"This title is of immense interest to researchers in the life sciences …[T]he book does provide more than 550 pages of information in 21 chapters focused on various compounds or classes thereof… In summary, most chapters of the book are well founded scientifically, with descriptions of recent research advances."—John Thor Arnason, PhD, director of biopharmaceutical sciences, University of Ottawa, Ontario, Canada, in HerbalGram, The Journal of the American Botanical Council‘This text could be used by phytochemists, medicinal chemists, and other natural products researchers. It is possible to be used by graduate students as a reference… Libraries supporting research or education efforts in natural products may find this beneficial for their reference shelf.’– Robert J. Krueger, Ferris St. University Big Rapids United States, for the J. Nat. Prod. 2018, 81, 216-216.‘This interesting book written by eminent chemists expert in the extraction and synthesis of natural bioactive ingredients, reports the relationship between the structure-activity of different compounds, focusing the attention on the state-of-the-art of their pharmaceutical effectiveness and safeness. For the accuracy of chemical activities and methodologies of production and control of the natural products reported, the book may be of high utility for specialists of the chemical and medical community who like to deepen chemistry and pharmacology of the plant ingredients as well as for students in chemistry who desire to enter in this fascinating field.’– P. Morganti Ph.D. – Editor-in-Chief, J. Appl Cosmetol.35, 183-186 (July/December 2017).