Chemical Biology of Natural Products

David J. Newman retired from the position of chief of the Natural Products Branch (NPB) in the Developmental Therapeutics Program at the National Cancer Institute (NCI) in Frederick, Maryland, in early January 2015. He is the author or coauthor of over 180 papers, reviews, and book chapters (and an editor, with Gordon M. Cragg and David Kingston, of Anticancer Agents from Natural Products), and holds 18 patents, mainly on microbial products. He is still associated with the NPB/NCI as a special volunteer and also has a small consulting business.Gordon M. Cragg obtained his undergraduate training in chemistry at Rhodes University, South Africa, and his DPhil (organic chemistry) from Oxford University.He has established collaborations between the NCI and organizations in many countries, promoting drug discovery from their natural resources. He has authored or coauthored over 180 papers, reviews, and book chapters.Paul G. Grothaus earned a BSChem from Creighton University in 1977 and his PhD from Purdue University in 1983, where he completed the first enantiospecific total synthesis of a trichothecene mycotoxin, anguidine.In 2007, he joined the Natural Products Branch of the National Cancer Institute in Frederick, Maryland, where he coordinates biomass collections, biological screening of extracts, and collaborations with external natural product researchers. Dr. Grothaus is the author or coauthor of 24 papers, reviews, and book chapters and holds 5 patents.

• Chapter 1: Microbial Genome Mining for Natural Product Drug DiscoveryChapter 2: Chemical Biology of Marine CyanobacteriaChapter 3: The Role of Combinatorial Biosynthesis in Natural Products DiscoveryChapter 4: The Generation of New to Nature Natural Products Through Synthesis and Biosynthesis: Blending Synthetic Biology with Synthetic ChemistryChapter 5: Terrestrial Microbial Natural Products Discovery Guided by Symbiotic Interactions and Revealed by Advanced Analytical MethodsChapter 6: Natural Products from Endophytic Microbes. Historical Perspectives, Prospects, and GuidanceChapter 7: Novel Insights in Plant Endophyte InteractionsChapter 8: Microbial Co-culture and OSMAC Approach as Strategies to Induce Cryptic Fungal Biogenetic Gene ClustersChapter 9: Natural Products of the Rhizosphere and Its Microorganisms: Bioactivities and Implications of OccurrenceChapter 10: Novel Metabolites from Extremophilic Microbes Isolated from Toxic Waste SitesChapter 11: Deep-Sea Hydrothermal Vent Organisms as Sources of Natural ProductsChapter 12: Cone Snail Venom Peptides and Future Biomedical Applications of Natural ProductsChapter 13: Naturally Occurring Disulfide-rich Peptides from Plants and Animals: Synthesis and BiosynthesisChapter 14: Synthesis and Target Identification of Natural Product Inspired Compound CollectionsChapter 15: On The Chemistry and Biology of the Marine Macrolides Zampanolide and Dactylolide