Chemical and Structural Approaches to Rational Drug Design

Inbunden, Engelska, 1994

Av David B. Weiner, William V. Williams, USA) Weiner, David B. (University of Pennsylvania, Philadelphia, Philadelphia,) Williams, William V. (University of Pennsylvania School of Medicine

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This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

Produktinformation

Utgivningsdatum1994-11-28
Mått178 x 254 x 20 mm
Vikt680 g
FormatInbunden
SpråkEngelska
SerieHandbooks in Pharmacology and Toxicology
Antal sidor290
FörlagTaylor & Francis Inc
ISBN9780849378188

Tillhör följande kategorier

Tillverkningsteknik inom Naturvetenskap och teknik
Farmakologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and Development of Receptor Antagonists 5. Molecular Targeting Chemistry in Rational Drug Design Section II: Structural Approaches to Rational Drug Design 6. The Role of X-Ray Crystallography in Structure-Based Rational Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8. Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of Immunomodulatory Peptides Based on Active Site Structures