Charney and Nestler's Neurobiology of Mental Illness

Inbunden, Engelska, 2025

Av Dennis Charney, Eric Nestler, Joseph D. Buxbaum, Elisabeth B. Binder, Joshua A. Gordon, Marina R. Picciotto, Icahn School of Medicine at Mount Sinai) Charney, Dennis (Dean, Dean, Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System) Nestler, Eric (Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs, Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs, Seaver Autism Center for Research and Treatment Department of Psychiatry Icahn School of Medicine at Mount Sinai) Buxbaum, Joseph D. (Professor, Professor, Max Planck Institute of Psychiatry) Binder, Elisabeth B. (Director, Department of Genes and Environment, Director, Department of Genes and Environment, National Institute of Mental Health) Gordon, Joshua A. (Director, Director, Yale University) Picciotto, Marina R. (Professor, Department of Psychiatry, Professor, Department of Psychiatry, Joseph D Buxbaum, Elisabeth B Binder, Joshua A Gordon, Marina R Picciotto

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The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry. Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders. In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders. The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.

Produktinformation

Utgivningsdatum2025-04-23
Mått223 x 282 x 52 mm
Vikt3 307 g
FormatInbunden
SpråkEngelska
Antal sidor1 096
Upplaga6
FörlagOUP USA
ISBN9780197640654

Tillhör följande kategorier

Psykiatri inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Dennis S. Charney, MD, Dean, Icahn School of Medicine at Mount Sinai, President for Academic Affairs, Mount Sinai Health System, Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, New York, NY USA. Joshua A. Gordon, MDDirector, National Institute ofEric J. Nestler, MD, PhD, , Nash Family Professor of Neuroscience, Director, Friedman Brain Institute, Dean for Academic Affairs, Icahn School of Medicine at Mount Sinai, Chief Scientific Officer of the Mount Sinai Health System, New York, NY, USA.Joseph D. Buxbaum, PhD, G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Deputy Chair, Department of Psychiatry, Director, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.Elisabeth B. Binder. MD, , Director, Department of Genes and Environment, Max Planck Institute of Psychiatr, Munich, GermanyJoshua A. Gordon, MD, Director, National Institute of Mental Health, Bethesda, MD, USA.Marina R. Picciotto, Charles B. G. Murphy Professor of Psychiatry and Professor, Child Study Center, of Neuroscience and of Pharmacology, Director, Division of Molecular Psychiatry, Deputy Chair for Basic Science Research, Dept. of Psychiatry, Deputy Director, Kavli Institute for Neuroscience, Co-Director, Neuroscience Research Training Program, Yale Department of Psychiatry, New Haven, CT, USA.

SECTION 1: EMERGING AND ESTABLISHED TECHNOLOGIESSection Editors: Eric J. Nestler and Kafui Dzirasa1. Genetic Methodologies and Applications Ben Neale2. Multiscale Network Approaches to Decode the Complexityof Common Human Diseases Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang3. The Role of the Epigenome in Brain Development, Function, and Disease Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos4. Methods for In Vivo Gene Manipulation Lisa M. Monteggia and Wei Xu5. Application of Stem Cells to UnderstandingPsychiatric Disorders Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges Lief E. Fenno and Karl Deisseroth 7. Methods for In Vivo Circuit Analysis Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman8. Magnetic Resonance Methodologies Hanzhang Lu and Peter A. Bandettini9. PET Brain Imaging Methodologies Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson10. Neuromodulation and Psychiatric Disorders Andrew Smith, Martijn Figee, and Helen MaybergSECTION 2: SCHIZOPHRENIASection Editors: Judy Ford and Dan Mathalon11. Diagnosis and Epidemiology of Schizophrenia Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina 12. Genetics of Schizophrenia Sophie E. Legge, Antonio F. Pardiñas, and Michael C. O'Donovan13. Neuroimaging and Circuit Mechanisms of Schizophrenia Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield14. Animal and Cellular Models for the Study of Schizophrenia Joshua A. Gordon15. Neural and Circuit Mechanisms of Schizophrenia Samuel J. Dienel and David A. Lewis16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human StudiesKowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy17. Translational Models for Psychotic SymptomsPhil Corlett 18. Current Treatments for SchizophreniaDonald C. Goff19. Novel Approaches for Treating SchizophreniaSteve M. Paul and Alan BreierSECTION 3: BIPOLAR DISORDERSection Editor: Alex Charney20. Diagnosis and Epidemiology of Bipolar DisorderKathleen R. Merikangas and Emma K. Stapp21. Genetics of Bipolar DisorderDongjing Liu and Niamh Mullins22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips23. Animal and Cellular Models for the Study of Bipolar Disorder Michael J. McCarthy and Jared W. Young24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human StudiesColleen A. McClung and Hilary P. Blumberg25. Current Treatments for Bipolar Disorder Nicole W. Simons and Alexander W. Charney26. Novel Approaches for Treating Bipolar DisorderNefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr. SECTION 4: DEPRESSION Section Editor: John Krystal27. Diagnosis and Epidemiology of Depression James W. Murrough28. Genetics of Depression Daniel Levey and Joel Gelernter29. Neuroimaging and Circuit Mechanisms of Depression Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli30. Animal Models for the Study of Depression Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bolaños-Guzmán31. Neurotrophic Mechanisms of Depression: Animal and Human Studies Lisa M. Monteggia32. Glial-Immune Mechanisms of Depression: Animal and Human Studies Georgia E. Hodes, Caroline Ménard, Madeline L. Pfau, and Scott J. Russo33. Neuroendocrine Mechanisms of Depression: Animal and Human StudiesElisabeth B. Binder and Jan M. Deussing34. Current Treatments for DepressionMaurizio Fava and John Krystal35. Novel Approaches for Treating Depression Eric J. Nestler, Dennis S. Charney, John H. Krystal, and James W. MurroughSECTION 5: ANXIETY AND TRAUMA-RELATED DISORDERSSection Editor: Kerry J. Ressler36. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma- and Other Stress-Related DisordersMurray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne37. Genetics of Anxiety and Trauma-Related DisordersSarah E. Benstock and John M. Hettema38. Neuroimaging and Circuit Mechanisms of Anxiety and Trauma-Related DisordersGregory A. Fonzo39. Animal Models for the Study of Anxiety Disorders Caroline Jia, Hao Li, and Kay Tye40. Biological Mechanisms of Anxiety Disorders: Animal and Human StudiesDanielle M. Gerhard, Anfei Li, Francis S. Lee, and Heidi C. Meyer41. Biological Mechanisms of Stress Resilience: Animal and Human Studies Saren H. Seeley, Sarah Boukezzi, Jonathan DePierro, Dennis S. Charney, and Adriana Feder 42. Current Treatments for Anxiety and Trauma-Related DisordersKristin L. Szuhany, Benjamin Feldman, Matteo Malgaroli, and Naomi M. Simon43. Novel Approaches for Treating Anxiety and Trauma-Related Disorders Alfred P. Kaye, Sarah Jefferson, and John H. KrystalSECTION 6: SUBSTANCE USE DISORDERSSection Editors: Nora Volkow and Yavin Shaham44. Epidemiology of Substance Use Disorders Denise B. Kandel, Pamela C. Griesler, Mei-Chen Hu, Philippe A. Melas, Bradley T. Kerridge, and Bridget F. Grant45. Genetics of Substance Use Disorders David Goldman and Danielle Sambo46. Neuroimaging and Circuit Mechanisms of Substance Use Disorders Edythe D. London, Chelsea L. Robertson, and Terry J. Prins47. Animal Models for the Study of Substance Use Disorders Christopher J. Evans, J. David Jentsch, Brigitte L. Kieffer, Rafael J. Maldonado, and Catherine M. Cahill48. Cellular and Molecular Mechanisms of Substance Use Disorders: Animal and Human Studies Kathryn J. Reissner49. Brain Development and the Risk for Substance Use DisordersSonia G. Ruiz, B.J. Casey, and Arielle Baskin-Sommers50. Current Treatments for Substance Use DisordersAdam D'Sa, Andrew L. Gaddis, and Eric C. Strain51. Novel Approaches for Treating Substance Use Disorders Matthew L. BanksSECTION 7: DEMENTIASection Editor: Alison M. Goate52. Diagnosis and Epidemiology of Dementia William C. Kreisl and Christiane Reitz53. Genetics of Alzheimer's Disease, Parkinson's Disease, and Lewy Body Dementia Alan E. Renton, Brian Fulton-Howard, Shea J. Andrews, Edoardo Marcora, and Alison M. Goate54. Neuroimaging and Fluid Biomarkers of Alzheimer's DiseaseBrian A. Gordon and Suzanne Schindler55. Molecular and Cellular Mechanisms of Alzheimer's Disease: Animal and Human StudiesGareth R. Howell and Gregory W. Carter56. Molecular and Cellular Mechanisms of Primary Tauopathies: Animal and Human Studies Shiaoching Gong and Li Gan57. Neurobiology of Lewy Body Dementias: Animal and Human Studies James E. Galvin and Jose Tomas Bras58. Current Treatments for Alzheimer's Disease and Other Dementias Mary Sano and Judith Neugroschil59. Novel Approaches for Treating Alzheimer's Disease and Other DementiasM. Catarina Silva, David C. Butler, Sally Temple, and Steve J. HaggartySECTION 8: PEDIATRIC PSYCHIATRIC DISORDERSSection Editor: Joseph D. Buxbaum60. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders Magdalena Janecka, Artemis Briasouli, Vahe Khachadourian, and Abraham Reichenberg61. Genetics of Pediatric-Onset Psychiatric Disorders Tess Levy and Joseph D. Buxbaum62. Neuroimaging in Pediatric Psychiatric Disorders Timothy P.L. Roberts and Luke Bloy 63. Neurobiology of Autism Spectrum Disorders and Intellectual Disability: Animal and Human Studies Alexandra Massa, Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R, Hof, and Alexander Kolevzon 64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies Tess Levy and Joseph D. Buxbaum65. Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies Christopher Pittenger66. Neurobiology of Eating Disorders: Animal and Human Studies Thomas Hildebrandt and Annabel Susanin67. Current Treatments for Pediatric Psychiatric Disorders Paige M. Siper, M. Pilar Trelles, Yael Kufert, and Dorothy E. Grice68. Novel Approaches for Treating Pediatric Psychiatric Disorders Niki P. Sabetfakhri and Edwin H. Cook, Jr. SECTION 9: FUTURE DIRECTIONS OF PSYCHIATRYSection Editor: Dennis S. Charney69. The Present and Future of Psychiatric Diagnoses Steven E. Hyman70. The NIMH Research Domain Criteria Project: Toward Precision Medicine in PsychiatryBruce N. Cuthbert71. Computational Psychiatry and the Bayesian Brain Karl J. Friston and Xiaosi Gu72. Digital Assessments of Psychiatric DisordersRachel E. Quist, Sukanya Bhattacharya, Sarah M. Chacko, and Nicholas C. Jacobson73. Digital Therapies of Psychiatric Disorders: Focus on Depression SymptomsBruno Biagianti, Mor Nahum, Neta Yitzhak, and Sofia Vinogradov74. Psychedelic Drugs as Treatment AgentsRachel Yehuda, Lauren A. Lepow, Philip A. Bonnano, Tamar Glatman Zaretsky, Josimar Hernandez Antonio, and Kathleen M. Jagodnik75. Psychiatry's Past Challenges and Future OpportunitiesRyan E. Lawrence and Jeffrey A. Lieberman