Characterization of Protein Therapeutics using Mass Spectrometry

Häftad, Engelska, 2015

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This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics.

Produktinformation

Utgivningsdatum2015-06-06
Mått155 x 235 x 27 mm
Vikt622 g
FormatHäftad
SpråkEngelska
Antal sidor404
FörlagSpringer-Verlag New York Inc.
ISBN9781489973641

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GUODONG CHEN, PHD, has extensive pharmaceutical research experience in major pharmaceutical companies, including Eli Lilly and Company, Schering-Plough and Bristol-Myers Squibb. Currently, he heads the analytical/mass spectrometry group at Bristol-Myers Squibb’s Princeton site in support of drug discovery programs and development projects in small molecule pharmaceuticals and biologics. He has over 65 research publications in peer-reviewed journals and book chapters, and three edited/co-edited books in pharmaceutical analysis. His other contributions to the scientific community include over 80 presentations at scientific conferences and academic institutes; service as a short course instructor, as session chair at various scientific forums, and as a reviewer for journals. He received his Ph.D. in Analytical Chemistry from Purdue University under the direction of Professor R. Graham Cooks.

Characterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions.- The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics.- Quantitative Analysis of Biologics Using Mass Spectrometry.- Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry.- Disulfide Linkages of an Albumin Fusion Protein.- Detailed Structural Characterization of Monoclonal Antibodies.- Application of Protein Mass Spectrometry in Impurity and Degradant Characterization.- Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting.- Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS.- Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry.- Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry.