The world is undergoing a profound transformation, driven by radical technological changes and an accelerated globalisation process. A new culture of greater resource efficiency and disruptive innovation will require new technologies, processes and materials, fostering new knowledge, innovation, education and a digital society, bringing forward new business opportunities and novel solutions to major societal challenges. Challenges for Technology Innovation: an Agenda for the Future is the result of the 1st International Conference on Sustainable Smart Manufacturing – S2M, held at the Faculty of Architecture in Lisbon, Portugal, on October 20-22, 2016. It contains innovative contributions in the field of Sustainable Smart Manufacturing and related topics, making a significant contribution to further development of these fields. This volume covers a wide range of topics including Design and Digital Manufacturing, Design Education, Eco Design and Innovation, Future Cities, Medicine 4.0, Smart Manufacturing, Sustainable Business Models, Sustainable Construction, Sustainable Design and Technology and Sustainable Recycling.