Cellular Endocrinology in Health and Disease

Alfredo Ulloa-Aguirre, M.D., D.Sc. is senior scientist in the Research Center for Population Health at the National Institute of Public Health and Professor ofthe National University of Mexico (UNAM), where he heads the Research Support Network of the National Institutes of Health in Mexico City. He received hisgraduate training in internal medicine and reproductive endocrinology at the National Institute of Medical Sciences and Nutrition SZ and earned the Doctoral degree in Medical Sciences from the UNAM. He received postdoctoral training at the University of Pennsylvania, Philadelphia PA, and has been visiting scientist at the Oregon National Primate Resarch Center, OHSU, Beaverton OR, and the Institut National de la Recherche Agronomique, in Tours, France (Le Studium Scientist). He is currently a member of the Studium Consortium for Research and Training in Reproductive Sciences (sCORTS, Le Studium, Orléans, France). An internationally recognized physician-scientist, Dr Ulloa-Aguirre has developed programmes in both clinical and basic research. His laboratory focuses on the structure-function relationship of gonadotropins and gonadotropin receptors as well as on the gonadotropin-releasing hormone receptor, with particular emphasis on the factors and mechanisms that control intracellular trafficking of these receptors. He is the author or co-author of over 165 research publications and several book chapters. Dr. Ya-Xiong Tao is currently Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA, Canada, China, India, and Mexico. He has edited ten volumes, including seven volumes in Progress in Molecular Biology and Translational Science. He teaches several courses, including Physiology, Receptorology, Genomics and Personalized Medicine, and Molecular Endocrinology, for veterinarian, graduate, and undergraduate Honors students.

• 1. Thyroid hormone receptors and their role in cell proliferation and cancer"2. The molecular cell biology of anterior pituitary cells3. Sensing calcium levels –the biology of the parathyroid cell 4. The biology of pituitary stem cells 5. The Na(+)/I(-) symporter and biosynthesis of thyroid hormones 6. The FSH signaling network in Sertoli cells7. Epigenetics and pituitary cell growth 8. Epigenetics and metabolic abnormalities 9. Unraveling the mechanisms underlying GnRH pulse generation: test of the proposed role for KNDy neurons10. Proteomics and Cellular Signaling11. Transcriptome analysis of adrenocortical cells in health and disease 12. Bone as an endocrine organ13. The control of steroidogenesis of adrenocortical cells14. The adipocyte as endocrine target 15. Insulin secreting cell lines: potential for research and diabetes therapy16. The architecture of human pancreatic islets as revealed by molecular imaging17. Computational models to decipher cell signaling pathways18. The regulation of theca cell-granulosa cell dialogue by endocrine and paracrine factors 19. Unraveling the mechanism of action of the GnRH pulse generator: the TAC3/TAC3R-dinorphin-Kiss1/Kiss1R neuronal connection20. Endocrinology of the single cell21. Altering aberrant intracellular trafficking of cell surface membrane receptors by pharmacological chaperones22. Deiodinases: taylors that suit intracellular thyronine demands23. Micro RNAs and non-coding RNAs in beta–cell function