Cellular Aging and Consequences in Humans

Dominique Meynial-Denis, Ph.D., studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and earned her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focusing on Human Nutrition. Consequently, she became a Nutritionist and specialized her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis earned a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. She was mainly interested in the effect of glutamine supplementation in advanced age. She was a member of the French Society of Enteral and Parenteral Nutrition (SFNEP), of the European Society of Clinical Nutrition and Metabolism (ESPEN) and of the International Association of Gerontology and Geriatrics (IAGG). She was a regular reviewer for different international nutrition journals.

• Chapter 1 - The role of epigenetic regulation in senescence and its implication in aging.Chapter 2 - Telomeres and age-related diseasesChapter 3 - Immune dysregulation and skeletal muscle regenerative failure in agingChapter 4 - Potential therapeutic agents targeting senescent cells and their influence on various organs and tissuesChapter 5 - Prevention and Management of Aging SkinChapter 6 - Age-associated Changes in Different Cell Types in the Brain.Chapter 7 - Stress, Neuronal Senescence and Brain AgingChapter 8 - Adjusting neuronal proteostasis to control life and health spanChapter 9 - Cellular Changes in Age-Related Hearing LossChapter 10 - Age-related Cardiac PathologiesChapter 11 - Cell senescence in kidney aging and in kidney diseaseChapter 12 - Cellular and molecular mechanisms contributing to senescence in sarcopeniaChapter 13 - Cellular senescence and skeletal muscle aging: Defining the role of essential amino acidsChapter 14 - Molecular mechanism of age-related disorder of skeletal muscle (sarcopenia)Chapter 15 - Stem cell aging and senescence in skeletal muscleChapter 16 - The role of vitamin D in telomere biologyChapter 17 - Dysphagia and the attenuating approach for aging and related disordersChapter 18 - The role of cellular senescence in tumorigenesis during agingChapter 19 - Rejuvenating Immunity with Aging: A Panacea for Carcinogenesis in Elderly Population