Del 0 - Healthy Ageing and Longevity

Cellular Ageing and Replicative Senescence

Häftad, Engelska, 2018

AvSuresh I.S. Rattan,Leonard Hayflick,Suresh I. S. Rattan

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This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer.

Produktinformation

Utgivningsdatum2018-05-26
Mått155 x 235 x 21 mm
Vikt563 g
FormatHäftad
SpråkEngelska
SerieHealthy Ageing and Longevity
Antal sidor364
FörlagSpringer International Publishing AG
ISBN9783319799124

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Geriatrik inom Medicin
Biologi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Preface.- Section I History and origins.- Origins of the Hayflick system, the phenomenon and the limit.- Early testing and development of the Hayflick system.- Section II Serial passaging and progressive changes.- Slowing down of the cell cycle.- Ageing of cells in the centenarians and long-lived .- Aging of the stem cells.- Aging and senescence in the immune cells in vitro and in vivo.- Accelerated cellular aging in progeroid syndromes.- Telomere and genomic instability.- Mechanistic explanation for cellular aging in vitro: the commitment theory.- Modelling cellular aging senescence.- Section-III Regulation, and senescence.- Cell cycle checkpoints and regulators of senescence.- Oxidative stress and cellular ageing.- Biomarkers of replicative senescence revisited.- Cellular aging and tumour regulation.- Declining Protein turnover and degradation.- Section IV Modulating the system.- Stress induced premature senescence (SIPS).- Mild stress-induced hormesis.- Food, hormones and growth factors in cellular aging.- sncRNAs in cellular aging and senescence.- Elimination of senescent cells for rejuvenation.- Section-V RECAPITULATION.- The past, present and the future of cellular aging and replicative senescence.- Index.