Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

• Section 1: Caveolae organization and role in lipid cholesterol metabolism.Lipid rafts and caveolae organization.Caveolae and the regulation of cellular cholesterol homeostasis.Section 2: Caveolae and the regulation of endocytosis.The Caveolae Internalization Machinery.Lipid raft mediated entry of bacteria into host cells.Section 3: Examples of the role of caveolins in cell signaling.The caveolin interaction with the endothelial nitric oxide synthase (eNOS).Caveolae and Estrogen Receptor Signaling.eNOS regulation by sphingosine 1-phosphate and caveolin.Insulin signaling and caveolae.Section 4: Caveolae and pathologies.Caveolin-3, Caveolae, and Hereditary Muscle Diseases.Caveolae and Caveolins in the Vascular System.Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.

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