Catalytic RNA

• Group I Ribozymes: Substrate Recognition, Catalytic Strategies and Comparative Mechanistic Analysis.- Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods.- The Structure of Group I Ribozymes.- Interaction of Aminoglycoside Antibiotics with RNA.- Catalytic Reaction Mechanisms and Structural Features of Group II Intron Ribozymes.- Structural Analysis of the Bacterial Ribonuclease P RNA.- Structural Analysis and Modifications of the Hairpin Ribozyme.- Circular RNAs: Generation of Small RNAs with Unique Properties by Splicing Permuted Intron-Exon Sequences.- Three-Dimensional Structure of the Hammerhead Ribozyme.- The Hammerhead Ribozyme.- Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes.- Mechanistic Studies on Hammerhead Ribozymes.- Hammerhead Ribozymes with Long Flanking Sequences: a Structural and Kinetic View.- Design, Synthesis and Function of Therapeutic Hammerhead Ribozymes.- Synthetic Catalytic Oligonucleotides Based on the Hammerhead Ribozyme.- Efficacy of Hammerhead Ribozymes Targeting ?-Lactalbumin Transcripts: Experiments in Cells and Transgenic Mice.- Anti-HIV Therapeutic Hammerhead Ribozymes: Targeting Strategies and Optimization of Intracellular Function.- Inhibition of HIV Replication by the Hairpin Ribozyme.- The Use of Ribozymes to Inhibit HIV Replication.- RNA Catalysis in Fungi.- In Vitro Selection of Catalytic RNA.- RNA Catalysis and Transition State Stabilization.- Subject Index for Volume 10.- Author Index for Volumes 6-10.- Subject Index for Volumes 6-10.

"This collection will provide a valuable resource to beginning investigators and to the general scientist who has kept abreast of the field to date." Cell "This volume is a rich source of information on catalytic RNA, with many of the major players contributing articles." Nature