Cardiovascular Genomics: New Pathophysiological Concepts

Proceedings of the 2001 European Science Foundation Workshop in Maastricht

Inbunden, Engelska, 2002

AvPieter A. Doevendans,European Science Foundation,P.A.F.M. Doevendans,Stefan Kääb,P. A. F. M. Doevendans

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This volume combines state-of-the-art chapters on technical advances in combination with applications in the different fields of cardiovascular medicine, including atherosclerosis, hypertension, cardiac hypertrophy and failure and arrhythmias. In addition, developments with respect to stem cell applications in cardiology are addressed, including cell source selection, manipulation and applications.

Produktinformation

Utgivningsdatum2002-07-31
Mått155 x 235 x 21 mm
Vikt617 g
FormatInbunden
SpråkEngelska
SerieDevelopments in Cardiovascular Medicine
Antal sidor275
Upplaga2002
FörlagKluwer Academic Publishers
ISBN9781402070228

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Hjärt- och kärlsjukdomar inom Medicin
Medicinsk genetik inom Medicin

1. Genomics and clinical cardiology: Hype or hope?.- Session 1: Gene expression analysis.- 2. Salt-sensitive hypertension: Identification of downstream renal targets in the aldosterone-signaling pathway by Serial Analysis of Gene Expression (SAGE).- 3. Cardiovascular proteomics: Effect of hypoxic conditions.- 4. Using comparative genome analysis to find interaction partners for frataxin.- Session 2: Genomics and pathophysiology of atherosclerosis.- 5. In vitro-in vivo gene expression analysis in atherosclerosis.- Session 3: Genomics in hypertension.- 6. Human essential hypertension: Role of the genes of the renin aldosterone system.- 7. Gene therapy for hypertension: Future or fiction?.- 8. Hormones and signalling pathways.- 9. Endothelial changes in hypertension.- Session 4: Genomics in cardiac hypertrophy and failure.- 10. Towards elucidation of genetic pathways in cardiac hypertrophy: Technique to develop microarrays.- 11. Gene expression in cardiac hypertrophy and failure: Role of G protein-coupled receptors.- 12. Little mice with big hearts: Finding the molecular basis for dilated cardiomyopathy.- 13. Cardiac hypertrophic signaling the good, the bad and the ugly.- Session 5: Molecular remodelling in arrhythmias.- 14. Ion channel regulation: From arrhythmias to genes to channels (to cures?).- 15. Differential expression and functional regulation of delayed rectifier channels.- 16. Genetic polymorphisms and their role in ventricular arrhythmias.- 17. Molecular mechanisms of remodeling in human atrial fibrillation.- 18. G-protein ß3-subunit polymorphism and atrial fibrillation.- Session 6: Towards cellular transplantion.- 19. Human stem cell gene therapy.- 20. Towards human embryonic stem cell derived cardiomyocytes.- 22. Cellular cardiac reinforcement.- 23. Appendixto session 3 hypertension Adducin paradigm: An approach to the complexity of hypertension genetics.