This issue of Anesthesiology Clinics, edited by Dr. Karsten Bartels and Dr. Stefan Dieleman in collaboration with Consulting Editor Dr. Lee Fleisher, focuses on�Cardiothoracic Anesthesia and Critical Care. Topics in this issue include:�Anesthetic Management for Endovascular Repair of the Thoracic Aorta;�Ethical Considerations for Mechanical Support;�Modulating Perioperative Ventricular Excitability; Echocardiography Education for Anesthesia Trainees; Mitochondrial Dysfunction After Cardiac Surgery; New Approaches to Perioperative Right Ventricular Assessment; New Techniques for Optimization of Donor Lungs/Hearts; Recent Developments in Catheter-Based Cardiac Procedures; Heart Failure in Adults with Congential Heart Disease; Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery; Advances in the Prevention of AKI Following Cardiac Surgery;�Clinical Trials That Should be Done in Cardiac Anesthesia; and Cardiac Surgery and the Blood-Brain Barrier.