Cardiac Remodeling

BARRY GREENBERG is Professor of Medicine and Director, Advanced Heart Failure Treatment Program, University of California, San Diego. He also serves on the Executive Steering and Safety Monitoring Boards of numerous national and international trials. Dr. Greenberg has published extensively on the basic cellular mechanisms of heart failure and the development of new forms of therapy for this condition. He is a member of the editorial board of several cardiology specialty and subspecialty journals and is an Associate Editor of the Journal of the American College of Cardiology. Dr. Greenberg is a founding member and current Vice President of the Heart Failure Society of America and has been continuously named in Best Doctors in America since 1994. Previously, Dr. Greenberg was a Fellow in Cardiology at the University of California, San Francisco. He received the B.A. degree from Brooklyn College, New York, the M.D. degree from the Upstate Medical Center, Syracuse, New York, and completed an internship and residency at the George Washington University Hospital, Washington, D.C., and the Yale-New Haven Hospital, Connecticut.

• Overview: What is Cardiac Remodeling? Structural and Mechanical Aspects of Remodeling. What Differentiates Physiological from Pathophysiologic Remodeling? Myocyte Signaling During the Transition from Hypertrophy to Heart Failure. Cardiac Myocyte Structural Remodeling. Myocyte Loss and Regeneration During Cardiac Remodeling. Role of the Interstitial Matrix in Maintaining Cardiac Function. Changes in the Interstitial Matrix During Cardiac Remodeling. Bioenergetic Abnormalities in the Remodeling Heart. Experimental Animal Models of Remodeling. The Use of Transgenic Animals to Study Cardiac Remodeling. The Effects of Pressure and Volume Load on Cardiac Structure and Remodeling. The Role of the Renin-Angiotensin Aldosterone System in Cardiac Remodeling. Adrenergic Pathways that Result in Cardiac Remodeling. Cytokines and Their Effects on Cardiac Remodeling. Other Factors Related to Cardiac Remodeling. Functional Consequences of the Remodeling Process. Epidemiology of Cardiac Remodeling. Clinical Assessment of Remodeling. Inhibition of the Renin-Angiotensin Aldosterone System. Effects of Adrenergic Blockade on Remodeling. Other Medical Therapies for Treating Cardiac Remodeling. The Effects of Cardiac Revascularization on the Remodeling Process. Valve Replacement and Repair. Cardiac Remodeling After LVAD Replacement. Cardiac Resynchronization Therapy. Other Surgical or Device-Based Approaches to Treating Cardiac Remodeling. Gene Transfer Therapy in the Treatment of Cardiac Remodeling. Future Strategies for Reversing the Remodeling Process