Carbonyl Reductase

Dr Liu Zhi-Qiang has been working for more than 20 years in industrialization of biomanufacturing. Dr Zhi-Qiang’s expertise lies in conducting cutting-edge research and technological advancements across the entire innovation chain, encompassing the discovery and design of functional proteins, the editing and reconstruction of artificial cells, and the control and integrated amplification of biotransformation processes. With a focus on optimizing enzymes for non-natural environments and unraveling the intricate regulation and coordination mechanisms of metabolic pathways, the applicant has made remarkable contributions to the field. They have successfully led numerous research projects, including the prestigious Zhejiang Provincial Key Research and Development Plan, and have published more than 100 articles in top-tier international journals. Their innovative work has resulted more than 70 authorized Chinese invention patents, 45 implementation of patented technologies in various enterprises, and the establishment of over 10 industrial production lines.

• Section 1 Discovery and Classification of Carbonyl Reductases1. Discovery of carbonyl reductases2. Classification of carbonyl reductasesSection 2 Molecular Basics of Carbonyl Reductase3. Stereoselectivity Catalytic Mechanism of Carbonyl Reductase4. Design and Molecular Modification of Carbonyl ReductaseSection 3 Coenzyme Systems5. Coenzyme Regeneration in Carbonyl Reduction ReactionSection 4 Application of Stereoselectivity Carbonyl Reductase in the Synthesis of Chiral Alcohol Pharmaceutical Intermediates6. Applications in Hypolipidemic Drugs7. Applications in Carbapenem Antibiotics8. Applications in Depression Treatment Drugs9. Applications in Anti-asthma Drugs10. Applications in Antihypertensive Drugs11. Applications in Anticoagulant Drugs12. Applications in Antiepileptic Drugs13. Applications in Non-Steroidal Anti-Inflammatory Drugs14. Applications in Anticancer Drugs15. Applications in anti-aids Drugs16. Applications in Adrenoceptor AgonistsSections 5 Application of carbonyl reductases in the synthesis of other fine chemicals17. Chirality γ- Pentolactone18. (2S, 3S) -2,3-butanediol19. Phenylethanol