Cannabinoids and Pain

Samer Narouze, MD, PhDNortheast Ohio Medical UniversityCenter for Pain MedicineWestern Reserve HospitalCuyahoga Falls, OH, USACaroline MacCallum, MD FRCPC, BSc PharmClinical Instructor Dept. of Med., Adjunct Professor Faculty Pharm. Sc.Associate. Member Division of Palliative Care|  University of British ColumbiaMedical DirectorGreenleaf Medical ClinicVancouver, BC, Canada

• History of Cannabis.- Cannabis Regulations.- The demand for medical cannabis education.- Pain physicians and cannabis: attitudes and beliefs.- Cannabis Terminology.- THE ENDOCANNABINOID SYSTEM.- The CB1 Receptors.- The CB2 Receptors.- Endocannabinoids: Anandamide and 2-AG.- Phytocannabinoids:Tetrahydrocannabinol (THC) .- Phytocannabinoids:  Cannabidiol (CBD).- Other Phytocannabinoids.- Cannabinoids Drug interaction.- Dronabinol (Marinol).- Nabilone (Cesamet).- Cannabidiol (Epidiolex).- Nabiximols (Sativex).- Medical Cannabis Strains.- The model of a specialized cannabis clinic.- Barriers for the prescription of cannabis-based medicines .- Practical recommendations for the use of medical cannabis.- Medical Cannabis Dosing and Titration.- Patient safety considerations.- Cannabinoids and Pain: Mechanisms of action .- Cannabinoids and Pain: Clinical Evidence.- Cannabinoids and Cancer Pain.- Cannabinoids as a substitute for opioids: Basic science and Clinical evidence.- Cannabiinoids as a substitute for opioids: Suggested algorithm .- Perioperative management of patients on cannabinoids.- The Colorado Experience.- Product Safety and Quality control.- Cannabis and brain development.- Cannabis and mental health risks.- Cannabis and adolescents.- Cannabis and child development during and after pregnancy.- Cannabis impairment and Adverse events.- Vaping hazards.- Cannabis Use Disorder.- Cannabis withdrawal  .- Future research.