Cancer Therapeutics

Experimental and Clinical Agents

Häftad, Engelska, 2010

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This comprehensive review of existing and potential anticancer drugs and therapies by leading researchers from academia, government laboratories, and pharmaceutical companies offers essential insight into what has been accomplished and where the experimental therapy of cancer is going. The authoritative contributors illuminate the current status of the major molecules of cancer treatment, ranging from the nitrogen mustards through platinum complexes to interferons, cytokines, growth factors and their inhibitors, and on to immunotoxins, antisense oligonucleotides, and gene therapy. A companion volume by the same editor (Anticancer Drug Development Guide: Preclinical and Clinical Screening and Approval) details the processes by which new anticancer drugs are approved. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.

Produktinformation

Utgivningsdatum2010-11-19
Mått178 x 254 x 25 mm
Vikt866 g
FormatHäftad
SpråkEngelska
SerieCancer Drug Discovery and Development
Antal sidor451
FörlagHumana Press Inc.
ISBN9781617370465

Tillhör följande kategorier

Farmakologi inom Medicin

I. Cytotoxic Agents: Old and New.- 1 Nitrogen Mustards.- 2 Phosphoramide and Oxazaphosphorine Mustards.- 3 Development of the Nitrosoureas.- 4 Platinum Complexes.- 5 Anthracyclines.- 6 Topoisomerase I Inhibitors.- 7 DNA Topoisomerase II Inhibitors.- 8 The Taxoids.- 9 Sequence-Selective Groove Binders.- 10 Bis-Naphthalimides: Synthesis and Preclinical Evaluation.- II. Newer Strategies and Targets.- 11 The Enediynes.- 12 Matrix Metalloproteinase Inhibitors.- 13 Interferons and Other Cytokines.- 14 Discovery of TNP-470 and Other Angiogenesis Inhibitors.- 15 Antisense Oligonucleotides.- 16 Growth Factors and Growth Factor Inhibitors.- 17 Immunoconjugates.- 18 A Case for ras Targeted Agents as Antineoplastics.- 19 Gene Therapy.