Cancer Prevention and Screening

ROSALIND A. EELES, MA (Cantab), PhD, FRCP, FRCR, FMedSCI is Professor of Oncogenetics and Team Leader in Oncogenetics at The Institute of Cancer Research and an Honorary Consultant in Cancer Genetics and Clinical Oncology at The Royal Marsden NHS Foundation Trust, London, UK CHRISTINE D. BERG, MD is Special Advisor to the Director, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, USA JEFFREY S. TOBIAS, MA (Cantab), MD, FRCP, FRCR is Professor of Cancer Medicine at the Department of Oncology, University College London, and Honorary Consultant at University College Hospital Foundation Trust, London, UK

• List of contributors viiForeword xiPrologue xiii1 Global perspectives surrounding cancer prevention and screening 1Peter David Sasieni and Donald Maxwell Parkin2 Public health perspectives surrounding cancer prevention and screening: The Ontario edition 19Linda Rabeneck and Arlinda Ruco3 Cancer screening: A general perspective 31Otis W. Brawley4 The balance of cancer screening risks and benefits 41Julietta Patnick5 Cancer screening issues in black and ethnic minority populations 51Otis W. Brawley6 Public awareness of cancer screening 57Jane Wardle and Laura A.V. Marlow7 Public understanding of cancer prevention 69Jessica Kirby and Sarah Woolnough8 Cervical cancer screening: An exemplar of a population screening programme and cervical cancer prevention 81Albert Singer and Ashfaq Khan9 Prevention of and screening for anal cancer 101Andrew E. Grulich Richard J. Hillman and Isobel M. Poynten10 The prevention of breast cancer 111Anthony Howell Michelle N. Harvie Sacha J. Howell Louise S. Donnelly and D. Gareth Evans11 Breast cancer: Population and targeted screening 129Fiona J. Gilbert Fleur Kilburn‐Toppin Valerie D.V. Sankatsing and Harry J de Koning12 Prostate cancer prevention 145Evan Kovac Andrew J. Stephenson Margaret G. House Eric A. Klein, and Howard L. Parnes13 Population screening for prostate cancer 171Richard J. Bryant Monique J. Roobol and Freddie C. Hamdy14 Colon cancer prevention 183John Burn and Harsh Sheth15 Colon cancer screening 203David F. Ransohoff16 Lung cancer prevention 217Jonathan M. Samet17 Lung cancer screening 237Christine D. Berg Kwun M. Fong and Henry M. Marshall18 Mesothelioma: Screening in the modern age 257Joanna Sesti Sabina Musovic Jessica S. Donington and Harvey I. Pass19 Skin cancer prevention and screening 275Mark Elwood and Terry Slevin20 Screening and prevention of oral cancer 295Apurva Garg Pankaj Chaturvedi and Rajiv Sarin21 Oesophageal cancer 309Timothy J. Underwood22 Hepatocellular carcinoma: Prevention and screening 317Aileen Marshall and Tim Meyer23 Ovarian cancer prevention and screening 331Aleksandra Gentry‐Maharaj Michelle Griffin and Usha Menon24 Screening for testicular cancer 349Kevin Litchfield Clare Turnbull and Robert A. Huddart25 Issues in paediatric cancers 361Jonah Himelfarb and David Malkin26 Obesity and dietary approaches to cancer prevention 381Andrew G. Renehan27 Risk profiling for cancer prevention and screening – lessons for the future 403Rosalind A. Eeles Paul Pharoah Alison Hall Susmita Chowdhury,and Hilary Burton28 Cancer prevention and screening: Advances to carry forward 417Christine D. Berg Rosalind A. Eeles and Jeffrey S. TobiasIndex 425