Cancer Genomics

• Introduction1. Historical OverviewMethodological Approaches and Background2. Expression Arrays (SNPs, etc.)3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas)6. Epigenetic Analyses7. Pharmcogenomics8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis11. Genomic Resource Projects – The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC)Ethics of Genomics Research 12. Ethics of Genomics Research The Genomics, Epigenomics and Transcriptomics of Cancer13. Somatic mutations, Transcription and Epigenetics OverviewAdult Solid Tumors14. Lung Cancer15. Breast Cancer16. Prostate Cancer17. Colon Cancer18. Thyroid CancerAge Non-specific Tumors and Hematopoietic Malignancies19. ALL 20. AML21. NHL22. Multiple Myeloma23. Brain TumorsPediatric Cancers24. Neuroblastoma25. Soft tissue sarcomas26. Osteosarcoma27. Wilms TumorsGermline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer SyndromesFuture Directions29. The role of microRNAs and ultraconserved non-coding RNAs in cancer30. Environmental impact on cancer genomics

"…provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies." --Anticancer Research 34, 2014