Cancer Drug Resistance

• Physiological Resistance.- The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors.- Influence of Tumor pH on Therapeutic Response.- Tumor Oxygenation and Treatment Response.- Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance.- PET Imaging of Response and Resistance to Cancer Therapy.- Biological Resistance.- Cancer Stem Cells Implications for Development of More Effective Therapies.- Therapeutic Resistance in Leukemia.- Tumor Site Implantation and Animal Model Selection in Oncology.- In Vivo Resistance.- Characteristics of the Metastatic Phenotype.- The Microenvironment and Drug Resistance.- Biochemical Resistance.- Glutathione and Glutathione S-Transferases in Drug Resistance.- Metallothioneins in Drug Resistance.- Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors.- New and Revised Concepts in Multidrug Resistance.- Cisplatin Resistance.- Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters.- Resistance To Taxanes.- CpG Island Methylation and Drug Resistance.- De Novo and Acquired Resistance to Antitumor Alkylating Agents.- Resistance to Antiangiogenic Agents.- The Role of Hormones, Growth Factors, and Oncogenes.- Resistance to Antiestrogens.- Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma.- Herceptin Resistance.- Role of TGF-? in Tumor Progression and Metastasis.- p53-Based Immunotherapy of Cancer.- Response and Resistance to Ionizing Radiation.- Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance.- Clinical Aspects of Resistance.- Cancer Chemotherapy.- Molecular Profiling in Breast Cancer.- Tumor Immune Escape Mechanisms.

"...a resource to scientists of diverse specialties with interests relating to the repsonse of malignant disease to current and experimental therapies." - Neoplasma "...an excellent book that is appropriate for scientists and clinicians with an interest in the basis of anticancer drug resistance." -Doody's Book Review, Weighted Numberical Score: 90 - 4 Stars!