Syed A. Abutalib, MD, is Assistant Director for Stem Cell Transplantation at the Chicago-area branch of Cancer Treatment Centers of America, or CTCA. CTCA is a group of five private treatment centers in the USA focused on patient care in oncology. For several years now, Dr. Abutalib has authored the very popular and well-received "Clinical Conundrums" feature in the oncologist tabloid paper Clinical Oncology (McMahon Publishing), and this is where the idea came to him to enhance and expand his concept from that experience into this book.Maurie Markman, MD, is Senior Vice President of Clinical Affairs and National Director of Medical Oncology at Cancer Treatment Centers of America (CTCA). A nationally-renowned oncologist, Dr. Markman has more than 20 years of experience in cancer treatment and gynecologic research at some of the country’s most recognized facilities. Dr. Markman has served as the Vice President for Clinical Research and Chairman of the Department of Gynecologic Medical Oncology at M.D. Anderson Cancer Center in Houston, Texas. Prior to that, Dr. Markman spent 11 years as Chairman of the Department of Hematology/Oncology and Director of the Taussig Cancer Center at the Cleveland Clinic Foundation. He also spent five years as Vice Chairman of the Department of Medicine at Memorial Sloan-Kettering Cancer Center in New York.

• List of Contributors, xPreface, xxiSection 1 Malignant Hematology and Hematopoietic Cell TransplantationPart 1 Acute Lymphoblastic Leukemia in Adults1 Diagnosis of acute lymphoblastic leukemia, 5Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde2 Prognostic markers and models in acute lymphoblastic leukemia, 18Dieter Hoelzer3 Management of B-cell acute lymphoblastic leukemia, 22Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour4 Management of T-cell acute lymphoblastic leukemia, 29Daniel J. DeAngelo5 Minimal residual disease in acute lymphoblastic leukemia, 35Meir Wetzler6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40Netanel A. Horowitz and Jacob M. RowePart 2 Acute Myeloid Leukemia in Adults7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51Gordana Raca, Madina Sukhanova, and Lucy A. Godley8 Induction therapy in acute myeloid leukemia, 58Tapan Kadia and Farhad Ravandi9 Consolidation therapy in acute myeloid leukemia, 67Gregory K. Behbehani and Bruno C. Medeiros10 Management of acute promyelocytic leukemia, 71Eytan M. Stein and Martin S. Tallman11 Minimal residual disease in acute myeloid leukemia, 76Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland12 Relapsed and refractory acute myeloid leukemia, 82Stefan H. Faderl13 Hematopoietic cell transplantation in acute myeloid leukemia, 89Antonio M. Jimenez and Stefan O. CiureaPart 3 Myelodysplastic Syndromes and Related Disorders14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99Jay Yang, Gail Bentley, and Charles A. Schiffer15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106Uma Borate and Harry P. Erba16 Management of myelodysplastic syndromes, 113Vu H. Duong, Alan F. List, and Rami S. Komrokji17 Management of therapy-related myeloid neoplasms, 120Jagoda K. Jasielec and Richard A. Larson18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei19 Acquired aplastic anemia, 131Valeria Visconte and Ramon V. TiuPart 4 Myeloproliferative Neoplasms20 Diagnostic approach in myeloproliferative neoplasms, 137Ayalew Tefferi21 Chronic myeloid leukemia: chronic phase, 142Jerald P. Radich 22 Blast crisis of chronic myeloid leukemia, 147Michael J. Mauro23 Chronic myeloid leukemia and pregnancy, 150Michael J. Mauro24 Polycythemia vera, 152Constantine S. Tam and Srdan Verstovsek25 Essential thrombocytosis, 156Paola Guglielmelli and Alessandro M. Vannucchi26 Primary myelofibrosis, 162Ayalew Tefferi27 Eosinophilic myeloproliferative disorders, 167Jason Gotlib28 Chronic myelomonocytic leukemia, 176Mrinal M. Patnaik29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180Jerald P. Radich30 Hematopoietic cell transplantation in primary myelofibrosis, 187Irum Khan and Damiano RondelliPart 5 Chronic Lymphocytic and Other Leukemias31 Prognostic markers and management of chronic lymphocytic leukemia, 195Courtney D. DiNardo and Susan O’Brien32 Hematopoietic cell transplantation in chronic lymphocytic leukemia, 201Michael R. Bishop33 Prolymphocytic leukemia, 207Claire Dearden34 Hairy cell leukemia, 220Justin M. Watts and Martin S. TallmanPart 6 Hodgkin Lymphoma35 Management of classical Hodgkin lymphoma, 229Kristen Sanfi lippo and Nancy L. Bartlett36 Nodular lymphocyte-predominant Hodgkin lymphoma, 235Dennis A. Eichenauer37 Hematopoietic cell transplantation in Hodgkin lymphoma, 240Tsiporah Shore and Koen van BesienPart 7 Non-Hodgkin’s Lymphomas38 Pitfalls in the diagnosis of non-Hodgkin’s lymphomas, 247Carmen Barcena and Laurence de Leval39 Follicular lymphoma, 257Myron S. Czuczman40 Diffuse large B-cell lymphoma, 263Andrew D. Zelenetz41 Mantle cell lymphoma, 270Stephen Smith and John Sweetenham42 Marginal zone lymphoma, 275Sarah Rutherford, Wayne Tam, and Peter Martin43 Primary mediastinal large B-cell lymphoma, 282Pier Luigi Zinzani44 Burkitt lymphoma, 286Mark Roschewski and Wyndham Wilson45 Gray zone lymphoma, 290Caron A. Jacobson and Ann S. LaCasce46 Transformed lymphoma, 295Stephane Doucet and Jane N. Winter47 HIV-associated lymphoma, 304Kieron Dunleavy48 Primary CNS lymphoma, 308Nicholas A. Blondin, Joachim M. Baehring, and Fred H. Hochberg49 Primary cutaneous lymphoma, 316Thomas M. Habermann50 Mycosis fungoides and Sézary syndrome, 323Stephane Dalle, Marie Perier-Muzet, Brigitte Balme, and Luc Thomas51 Hematopoietic cell transplantation in indolent non-Hodgkin’s lymphoma, 327Saurabh Chhabra and Ginna G. Laport52 Hematopoietic cell transplantation in diffuse large B-cell lymphoma, 332Syed A. Abutalib and Istvan Redei53 Hematopoietic cell transplantation in T-cell non-Hodgkin’s lymphomas, 339Lori S. Muffly and Sonali M. SmithPart 8 Plasma Cell Neoplasms and Related Disorders54 Smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, 347Robert A. Kyle55 Risk stratification and response assessment in multiple myeloma and Waldenström’s macroglobulinemia, 352Silvia Gentili and Sagar Lonial56 Treatment of multiple myeloma, 358Cindy Varga, Claudia Paba Prada, Kenneth Anderson, and Paul Richardson57 Light-chain amyloidosis, 366David C. Seldin58 Waldenström’s macroglobulinemia, 371Anita D’Souza and Morie A. Gertz59 Autologous hematopoietic cell transplantation in multiple myeloma, 376Jean-Luc Harousseau and Mohamad Mohty60 Allogeneic hematopoietic cell transplantation in multiple myeloma, 381Jasleen Randhawa, Veerpal Singh, and Parameswaran HariPart 9 Special Issues in Hematology61 Role of PET scan in lymphomas, 391Matthew A. Lunning and James O. Armitage62 Radioimmunotherapy in lymphomas, 398Reem Karmali and Stephanie A. Gregory63 Radiation oncology consultation for hematologic malignancies, 403Chris R. Kelsey and Leonard R. ProsnitzPart 10 Special Issues in Hematopoietic Cell Transplantation64 Donor and graft selection in allogeneic hematopoietic cell transplantation, 411Jose Leonel Ochoa-Bayona and Claudio Anasetti65 Preparative regimens in allogeneic hematopoietic cell transplantation for malignant hematologicaldiseases, 417Robert J. Soiffer66 T-cell depletion in allogeneic hematopoietic cell transplantation, 421Jenna D. Goldberg and Miguel-Angel Perales67 Prevention and treatment of relapse following hematopoietic cell transplantation, 426Robert Chen, Sandra Thomas, and Stephen J. Forman68 Acute graft-versus-host disease, 432Andrew C. Harris and John E. Levine69 Chronic graft-versus-host disease, 438Carrie L. Kitko and Daniel R. CourielSection 2 OncologyPart 1 Central Nervous System Tumors70 Primary brain tumors, 449Barbara J. O’Brien and Mark R. Gilbert71 Secondary brain and spinal cord tumors, 457Rimas V. Lukas, Patrik Gabikian, and Steven J. ChmuraPart 2 Head and Neck Cancers and Thoracic Malignancies72 Medical management of head and neck cancers, 467Tobenna Nwizu and David Adelstein73 Endocrine malignancies, 476Ann W. Gramza74 Methodological and practical challenges for personalized therapies in non-small-cell lung cancer, 480Ignacio I. Wistuba75 Screening, staging, and stage I non-small-cell lung cancer, 486Tarek M. Mekhail76 Stage II and III non-small-cell lung cancer, 493Grzegorz Korpanty and Natasha B. Leighl77 Recurrent and metastatic non-small-cell lung cancer and novel targets, 500Evan Pisick and Ravi Salgia78 Small-cell lung cancer, 503Stephen V. Liu and Glen J. Weiss79 Mesothelioma, 506Christopher W. Towe and Harvey I. PassPart 3 Breast Cancer80 Immunohistochemistry testing and beyond in breast cancer, 515Alejandro A. Gru and D. Craig Allred81 Prevention and adjuvant therapy in breast cancer, 523Faithlore P. Gardner and Edith A. Perez82 Preoperative systemic therapy for breast cancer, 532Virginia Kaklamani and William J. Gradishar83 Recurrent and metastatic breast cancer, 540Dennis L. Citrin84 Special issues in the young and pregnant patient with breast cancer, 546Hatem A. Azim Jr. and Fedro A. PeccatoriPart 4 Gastrointestinal Oncology85 Early-stage esophageal and stomach cancers, 555M. Naomi Horiba and Yixing Jiang86 Metastatic esophagogastric cancer: controversies, consensus, and new targets, 562Geoffrey Y. Ku and David H. Ilson87 Early-stage colorectal cancer, 567Vaibhav Sahai and Al B. Benson III88 Recurrent and metastatic colorectal cancer: controversies, consensus, and new targets, 573Davendra Sohal and Robert J. Pelley89 Pancreatic cancer, 581Katherine Van Loon and Margaret Tempero90 Hepatobiliary cancer, 590Keith Stuart91 Neuroendocrine tumors, 595Anya Litvak and Leonard Saltz92 Transarterial liver-directed therapies in oncology, 601Divyesh G. Mehta and Jeffery Choh93 Anal cancer, 606Rob Glynne JonesPart 5 Genitourinary Oncology94 Renal cancer: tumor diversity, molecular taxonomy, and prognostic algorithms, 615Henry J. Conter and Eric Jonasch95 Medical management of renal cancer, 621Gary R. MacVicar and Timothy M. Kuzel96 Medical management of bladder cancer, 628Gary R. MacVicar and Timothy M. Kuzel97 Prostate cancer: Screening, surveillance, prognostic algorithms and independent pathologic predictiveparameters, 634Megan G. Lockyer and Thomas M. Wheeler98 Medical management of prostate cancer, 638Elizabeth K. O’Donnell and Philip Kantoff99 Germ cell tumors, 645Timothy GilliganPart 6 Skin Malignancies100 Medical management of melanoma, 653Ana M. Ciurea and Kim Margolin101 Nonmelanoma skin cancers, 661Daniel Christiansen and Anna Sancho ClaytonPART 7 Gynecological Malignancies102 Ovarian cancer: neoadjuvant, adjuvant, and surgical issues, 669Alpa M. Nick and Robert L. Coleman103 Ovarian cancer: second-line treatment strategies, 675Maurie Markman104 Endometrial and cervical cancers, 681Maurie MarkmanPART 8 Sarcomas105 Bone sarcomas, 689Nicole Larrier, William C. Eward, and Richard F. Riedel106 Soft tissue sarcomas, 696Neeta Somaiah and Shreyaskumar PatelPART 9 Multidisciplinary Approach: Consultation with Surgical Oncology Team107 Surgical aspects of head and neck cancers, 707Constance E.H. Teo and Randal S. Weber108 Surgical aspects of thoracic malignancies, 711Albert S.Y. Chang, Thomas A. D’Amico, and David C. White109 Surgical aspects of upper gastrointestinal cancers, 719Sabha Ganai and Mitchell C. Posner110 Surgical aspects of pancreatic cancer, 723Amanda B. Cooper, Ching-Wei D. Tzeng, and Matthew H.G. Katz111 Surgical aspects of hepatobiliary tumors, 729Subhasis Misra and Leonidas Koniaris112 Surgical aspects of lower gastrointestinal cancers, 735Anthony J. Senagore113 Surgical aspects of renal cancer, 739Michael E. Woods and Matthew C. Raynor114 Surgical aspects of bladder cancer, 744Michael B. Williams115 Surgical aspects of prostate cancer, 747Peter Pinto116 Surgical aspects of melanoma, 754Thomas VelanciaPART 10 Multidisciplinary Approach: Consultation with Radiation Oncology Team117 Radiotherapy for head and neck cancers, 761Shiyu Song118 Radiotherapy for ductal carcinoma in situ (DCIS), 767Beryl McCormick119 Radiotherapy for early-stage invasive breast cancer, 771Julia White120 Radiotherapy for thoracic malignancies, 778Meredith E. Giuliani and Andrea Bezjak121 Radiotherapy for gastrointestinal malignancies, 785Manisha Palta, Christopher Willett, and Brian Czito122 Radiotherapy for genitourinary malignancies, 789Christina H. Chapman and Curtiland DevillePART 11 Hereditary Cancer Syndromes and Genetic Testing in Oncology123 When to suspect hereditary cancer syndromes, 795Emily Dalton and Kathy Schneider124 Hereditary breast cancer syndromes, 800Kathy Schneider and Emily Dalton125 Genetic testing in gastrointestinal tumors, 804Kristen M. Shannon and Daniel C. Chung126 Hereditary urogenital cancer syndromes, 810Melanie Corbman and Eric FowlerPART 12 Special Issues in Hematology and Oncology127 Carcinoma of unknown primary (CUP), 817Isabella C. Glitza and Gauri R. Varadhachary128 Geriatric oncology, 822Nayana Kamath and Supriya Gupta Mohile129 Nuts and bolts of cancer immunotherapy, 826Christopher R. Heery and James L. Gulley130 Controversies related to oncology clinical trial development, 831Elihu H. Estey131 PET scan in oncology, 835Shaunagh McDermott and Michael A. Blake132 Hematopoietic growth factors, 841LeAnn B. Norris, Jametta Magwood, and Charles L. Bennett133 Anticoagulation issues in oncology, 844Steven M. Corsello and Jean Marie Connors134 Symptom management and palliative care, 851Rony Dev and Eduardo D. Bruera135 Metabolic and nutritional issues in oncology, 860Julia Fechtner, Carolyn Lammersfeld, Carol Ireton-Jones, and Pankaj Vashi136 Bone-related issues in oncology, 867S. Mujtaba Rizvi, Helen Collins, and Alan Lipton137 Integrative medicine in oncology, 872Weidong Lu and David S. Rosenthal138 Naturopathic medicine in oncology, 879Christina M. Shannon, Tracey Thomas, and Shauna Birdsall139 Anesthesiology consultation for localized cancer pain, 884Abed Rahman, Magdalena Anitescu, and Raed Rahman140 Musculoskeletal care in oncology, 893James E. Rosenberg and Charles A. McDonald141 Cancer survivorship and psychosocial issues in oncology, 896Jabeen Abutalib, Shahid Raza, and Laura SunnIndex, 902Color plate section facing p.522