Del 255 i serien Handbook of Experimental Pharmacology

Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Focus on Migraine

Häftad, Engelska, 2020

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Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Produktinformation

Utgivningsdatum2020-09-11
Mått155 x 235 x 12 mm
Vikt312 g
FormatHäftad
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor192
FörlagSpringer Nature Switzerland AG
ISBN9783030214562

Tillhör följande kategorier

Smärta och smärtbehandling inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Neurologi och klinisk neurofysiologi inom Medicin
Farmakologi inom Medicin

1. CGRP Discovery and Timeline.- 2. CGRP Receptor Biology: Is There More Than One Receptor?.- 3. The Structure of the CGRP and Related Receptors.- 4. CGRP Receptor Signalling Pathways.- 5. Pathways of CGRP Release from Primary Sensory Neurons.- 6. CGRP in Animal Models of Migraine.- 7. CGRP in Human Models of Migraine.- 8. Role of CGRP in Migraine.- 9. Understanding CGRP and Cardiovascular Risk.- 10. CGRP and Painful Pathologies other than Headache.- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.