This book constitutes the refereed proceedings of the 12h International Symposium on Business Modeling and Software Design, BMSD 2022, which took place in Fribourg, Switzerland, in June 2022.The 12 full and 9 short papers included in this book were carefully reviewed and selected from a total of 56 submissions. BMSD is a leading international forum that brings together researchers and practitioners interested in business modeling and its relation to software design. Particular areas of interest are: Business Processes and Enterprise Engineering; Business Models and Requirements; Business Models and Services; Business Models and Software; Information Systems Architectures and Paradigms; Data Aspects in Business Modeling and Software Development; Blockchain-Based Business Models and Information Systems; IoT and Implications for Enterprise Information Systems. Each year, a special theme is chosen, for making presentations and discussions more focused.The BMSD 2022 theme is: Information Systems Engineering and Trust.