Bone Marrow Transplantation

Richard K. Burt Northwestern University, Chicago. H. Joachim Deeg Fred Hutchinson Cancer Centre, Seatlle, Washington. Scott Thomas Lothian, Northwestern Memorial Hospital, Chicago. George W. Santos, Johns Hopkins University, Balitmore, USA.

• 1.0 General 1.1 History of Bone Marrow Transplantation 1.2 Bone Marrow Transplantation Unit 1.3 Patient and Donor Evaluation 1.4 Bone Marrow Transplantation from Unrelated Donors 1.5 Costs of Care for Bone Marrow Transplantations for Malignant Hematopoietic Diseases 2.0 Transplantation Procedures 3.0 Transfusion Medicine in Marrow and Blood Cell Transplantation 3.1 Transfusions 3.2 Hematopoietic Progenitor Stem Cells 3.3 Purging of Bone Marrow and Peripheral Blood Stem Cells 3.4 Marrow Processing and Cryopreservation 4.0 Cytoreduction4.1 Conditioning (Preparative) Regimens 4.2 Total Body Irradiation 4.3 High-Dose Alkylating Agent Pharmacology/Toxicity 5.0 MHC and Bone Marrow Transplantation 6.0 Diseases 6.1 Aplastic Anemia 6.2 Acute Myeloid Leukemia— A M L 6.3 Adult Acute Lymphoblastic Leukemia 6.4 Chronic Myeloid Leukemia— C M L 6.5 Chronic Lymphocytic Leukemia 6.6 Multiple Myeloma 6.7 Bone Marrow Transplantation in Lymphomas 6.8 Adult Solid Tumors 6.9 Bone Marrow Transplantation for Pediatric Malignancy 6.10 Hereditary Disorders of the Immune System Treatable by Bone Marrow Transplantation 6.11 Lysosomal and Peroxisomal Storage Diseases 6.12 The Clinical Management of Thalassemia Patients Undergoing Bone Marrow Transplantation 6.13 Bone Marrow Transplantation for Sickle Cell Anemia 7.0 Engraftment 7.1 Approaches to Evaluation of Chimerism and Clonality 7.2 Graft Failure 7.3 Minimal Residual Disease 7.4 Relapse After Bone Marrow Transplantation 8.0 General Medical Care 8.1 Diagnosis and Management of Complications Related to Long-Term Venous Access Devices 8.3 Management of Pain in the Bone Marrow Transplant Patient 8.4 Cardiovascular Support 8.5 Respiratory Support 8.6 Disorders of Renal Function and Electrolytes 9.0 Growth Factors 10.0 Infections 10.1 Infection Prophylaxis in Bone Marrow Transplant Recipients—Myths, Legends and Microbes 10.2 Approaches to Management of Invasive Fungal Infections in Bone Marrow Transplant Recipients 10.3 Virus Infections Complicating Bone Marrow Transplantation 11.0 Craft-Versus-Host Disease 12.0 Graft-Versus-Leukemia Effect of Allogeneic BMT 13.0 Toxicity 13.1 Regimen Related Toxicity— First 30 Days Early Toxicity of High Dose Therapy 13.2 Delayed Complications 14.0 Outpatient Management of Marrow and Blood Stem Cell Transplant Patients 16.0 Medications