Dr. Qian received her bachelor’s degree in public health, a Master’s in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded “New Century Outstanding Talents of the Ministry of Education”, “The 9th Shaanxi Youth Science and Technology Award”, “The 2nd Xi'an Young Science and Technology Talent Award”, and “Elsevier 2021 Most Cited Chinese Researchers”. Dr. Lifang Hu is an associate professor in the School of Life Science and Technology at Northwestern Polytechnical University, Xi’an, China. She has an interdisciplinary background spanning mechanobiology, aging biology, bone diseases, cell and molecular biology and aerospace medicine research. She has a strong publication record, has previously edited one book and holds more than 10 patents. She was awarded the Outstanding Paper Award for Young Scientists by the Committee on Space Research (COSPAR). She is a member of the Chinese Society of Biomechanics, American Society of Bone and Mineral Research, and a lifetime member of International Chinese Musculoskeletal Research Society. Dr. Hu is the Associate Editor of Frontiers in Physiology and Editorial Board Member of Scientific Reports and BMC Musculoskeletal Disorders. She also serves as Guest Editor for Seminars in Cell and Developmental Biology and Frontiers in Cell and Developmental Biology.

• 1. Introduction 2. Methods and models for the study of bone cell mechanobiology 3. Osteocyte Mechanobiology 4. Bone marrow mesenchymal stem cell (BM-MSC) Mechanobiology 5. Osteoblast Mechanobiology 6. Osteoclast Mechanobiology 7. Crosstalk among bone cells mechanotransduction 8. Bone cell biomechanics and the whole bone mechanic property 9. Chondrocyte mechanobiology 10. Bone cell and chondrocyte mechanobiology in bone diseases 11. New technologies for bone cell study