Blood and Marrow Transplant Handbook

Richard T. Maziarz, MDProfessor of MedicineAdult Blood and Marrow Stem Cell Transplant & Cell Therapy ProgramKnight Cancer InstituteOregon Health & Science UniversityPortland, OR USASusan Schubach Slater, BSN, MN, FNP-BCAssistant Professor of MedicineAdult Blood and Marrow Stem Cell Transplant & Cell Therapy ProgramKnight Cancer InstituteOregon Health & Science UniversityPortland, OR USA

• Overview of Hematopoietic Stem Cell Transplantation & Cellular Therapy.- The Business of Cellular Therapy and Hematopoietic Stem Cell Transplantation.- Hematopoietic Stem Cell Sources and Donor Selection.- Pre-transplant Assessment for Hematopoietic Stem Cell Transplantation Recipients and Donors.- Social Work:  Evaluation and Social Supports.- Conditioning Regimens.- Nutrition.- Physical and Occupational Therapy.- Adolescent and Young Adult Concerns.- Infection Prevention and Prophylaxis.- Graft-versus-Host Disease (GvHD) Prophylaxis.- Transfusion Medicine.- Anticoagulation and Antiplatelet Guidelines.- Engraftment.- Acute Myeloid Leukemia and Allogeneic Hematopoietic Stem Cell Transplant.- Acute Lymphoblastic Leukemia.- Hodgkin Lymphoma and non-Hodgkin Lymphoma.- Multiple Myeloma.- HSCT for Germ Cell Tumors.- Hematopoietic Stem Cell Transplant for Myelofibrosis.- Chronic Myeloid Leukemia.- Chronic Lymphocytic Leukemia.- Hematopoietic Stem Cell Transplant for Severe Aplastic Anemia.- Inherited Disorders.- Hematopoietic Cell Transplant and Cellular Therapies for Sickle Cell Disease.- Radiology Pearls for the Transplant Provider.- Acute Graft-Versus-Host Disease (GvHD).- Chronic Graft-versus-Host Disease.- Immune Reconstitution.- Infectious Complications.- Oral Complications.- Gastrointestinal Complications.- Pulmonary Complications.- Cardiovascular Complications.- Kidney Disease in Hematopoietic Stem Cell Transplantation.- Neurological Complications.- Endocrine Complications following Hematopoietic Stem Cell Transplantation.- Thrombotic Microangiopathies.- Women’s Health Care.- Men’s Health for Bone Marrow Transplant Patients.- Psychiatric Complications.- Graft Failure.- Second Primary Malignancies.- Relapse after Hematopoietic Stem Cell Transplantation.- Safe Pain Management with Opioids in Post-Transplant Patients.- Complementary Medicine: Acupuncture.- Complementary Medicine.- Complementary Medicine: Cannabinoids and the Hematopoietic Stem Cell Transplant(HSCT) Recipient.- Management of Neurocognitive Effects and Fatigue During and After Stem Cell Transplant.- Palliative Care.- Long-Term Follow Up and Survivorship.- CAR T Cells for Hematologic Malignancies.- Natural Killer Cell Therapy in Allogeneic Stem Cell Transplant.- Mesenchymal stromal cells: Impact on hematopoietic cell transplantation.- T cell Therapeutics: Donor Lymphocyte Infusion, Cytotoxic T Lymphocyte Infusion and Other Non-CAR T cell Therapies.- Dendritic Cell Vaccines.- BiTEs, DARTs and Peri-Transplant Minimal Residual Disease.- CAR T Toxicity Management: Cytokine Release Syndrome and Neurotoxicity.- Molecular testing for post-transplant surveillance.- Management of Immune Compromised Transplant and Immune Effector Cell Treated Patients in the Setting of the COVID-19 Viral Pandemic: the OHSU Experience.- Appendix 1: The Vocabulary of Transplant.- Appendix 2: Procedure - Bone Marrow Aspirate and Biopsy.- Appendix 3: Procedure - Lumbar Puncture.- Appendix 4: Procedure - Ommaya reservoir tap.- Appendix 5: Procedure - Skin Biopsy.- Appendix 6: OHSU Food Safe Diet.- Appendix 7: OHSU Low Bacteria Diet.- Appendix 8: OHSU’s Graft-versus-host disease diet.- Appendix 9:  OHSU vaccine guidelines.- Appendix 10:  OHSU Donor and stem cell source selection in allogeneic hematopoietic progenitor cell transplantation.