Bioreactor Design Concepts for Viral Vaccine Production

Surajbhan Sevda is currently an Assistant Professor at the Department of Biotechnology, National Institute of Technology, Warangal, India. Prior to this, he was a technical officer (research scientist) at IIT Guwahati, India. He completed his Doctoral Degree in 2013 from Indian Institute of Technology, New Delhi, India. He was a visiting scientist at University of Calgary, Canada in 2018. His research experience lies in the bioreactor design, modelling of microbial growth, biofuels, and bioenergy, life cycle analysis (LCA), metal recovery, biosensor development, green chemistry, microbial electrosynthesis, enzyme and antibiotic production.Dr. Sachin Kumar is currently working as Associate Professor at the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India. He obtained his Ph.D. in molecular virology from University of Maryland in 2010. His research area is viral Immunology, in broad sense, is the study of viral infections in context of immune responses to such infections which can cause deleterious effect on the functions of the cells. Viruses are highly adaptable and have developed ways to avoid detection by specific immune cells. Immune response to a virus follows a cascade of steps and different routes: via specific targeting cytotoxic immune cells, or chemicals such as interferon, or via antibody binding and subsequent complement system activation. Our current understanding of host immune responses to viruses has progressed in recent years, and 'Viral Immunology' as an area has established itself as a sub-discipline of 'Immunology' tackling the immunological context in viral infections.

• 1. Introduction: Understanding of Bioreactor2. Stoichiometry for Biochemical Process3. Biochemical aspects of bioreactor operation4. Scale-Up of Cell-Culture Bioreactors5. Application of modeling in bioreactor design and analysis6. Vaccine and Vaccine types7. Development a new vaccine at lab scale8. Animal cell cultivation in bioreactor9. Characterization of cultured animal cells10. Bioreactor design for vaccine production11. Advance development in membranes for virus producing bioreactors12. Downstream Processing for vaccines13. Vaccine against RNA viruses14. Vaccine against DNA viruses15. Development of a bioprocess for rotavirus vaccine16. Single-use fixed bed bioreactor for scalable virus production17. Production of rabies vaccine in the large-scale bioreactor18. Bioreactor for hepatitis C virus vaccine19. Bioreactor for Vero cell for the production of viral vector and vaccines.20. Titration and dose calculation of the vaccine stock21. Bioreactor process development for DNA vaccine production