Biomolecular Thermodynamics

Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned a Ph.D. in biochemistry from Stanford University (1993) and Ph.D. in biophysics and structural biology from the University of Oregon (1996). He has been honored as recipient of the Beckman Young Investigator award, the Helen Hay Whitney Postdoctoral fellowship, and Howard Hughes Medical Institute Predoctoral Fellowship. He has been an editorial board member of the journals Protein Science and Biophysical Journal, and has been an organizer of the Gibbs Conference on Biothermodynamics. Research in his lab focuses on the study of protein evolution, folding, and assembly.

• Series PrefacePrefaceAcknowledgmentsNote to InstructorsAuthorChapter 1 Probabilities and Statistics in Chemical and BiothermodynamicsChapter 2 Mathematical Tools in ThermodynamicsChapter 3 The Framework of Thermodynamics and the First LawChapter 4 The Second Law and EntropyChapter 5 Free Energy as a Potential for the Laboratory and for BiologyChapter 6 Using Chemical Potentials to Describe Phase TransitionsChapter 7 The Concentration Dependence of Chemical Potential, Mixing, and ReactionsChapter 8 Conformational EquilibriumChapter 9 Statistical Thermodynamics and the Ensemble MethodChapter 10 Ensembles That Interact with Their SurroundingsChapter 11 Partition Functions for Single Molecules and Chemical ReactionsChapter 12 The Helix–Coil TransitionChapter 13 Ligand Binding Equilibria from a Macroscopic PerspectiveChapter 14 Ligand Binding Equilibria from a Microscopic PerspectiveAppendix: How to Use Mathematica 485BibliographyIndex

"Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University"a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter. The focus on biomolecules combined with the detailed demonstrations of how concepts apply to practical aspects of biophysics make this a truly unique contribution. Everyone, from the purported expert to the true novice will gain immensely from this carefully crafted, well motivated, and deeply thought out contribution. This book should live on all of our bookshelves and be consulted routinely as a quick reference or as material for in depth study and training." —Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis"The author has created an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus. It starts by bringing students up to speed on probability theory, multi-variate calculus and data fitting, the necessary tools for tackling the advanced topics covered in the remaining dozen chapters and for conducting rigorous interdisciplinary research…. the ample problems and tutorials throughout are much appreciated." —Tobin R. Sosnick, Professor and Chair, Dept of Biochemistry and Molecular Biology, University of Chicago