Johnna S. Temenoff and Antonios G. Mikos, co-authors of Biomaterials: The Intersection of Biology and Materials Science, have been chosen to receive the 2010 Meriam/Wiley Distinguished Author Award from the American Society for Engineering Education (ASEE). This marks the first time that authors of a biomedical engineering textbook have been recognized with this award.

• Chapter 1: Materials for Biomedical Applications 1-11.1. Introduction to biomaterials 1-21.2. Biological response to biomaterials 1-81.3. Biomaterial product testing and FDA approval 1-101.4. Types of biomaterials 1-111.5. Processing of biomaterials 1-151.6. Important properties of biomaterials 1-161.7. Principles of chemistry 1-211.8. Summary 1-351.9. Problems 1-371.10. Tables 1-391.11. Figures 1-441.12. References 1-701.13. Additional reading 1-72Chapter 2: Chemical Structure of Biomaterials 2-12.1. Introduction: Bonding and the structure of biomaterials 2-22.2. Structure of Metals 2-22.3. Structure of Ceramics 2-182.4. Structure of polymers 2-242.5. Techniques: Introduction to material characterization 2-412.6. Summary 2-622.7. Problems 2-642.8. Tables 2-692.9. Figures 2-792.10. References 2-1482.11. Additional reading 2-149Chapter 3: Physical Properties of Biomaterials 3-13.1. Introduction: From atomic groupings to bulk materials 3-23.2. Crystallinity and linear defects 3-23.3. Crystallinity and planar defects 3-83.4. Crystallinity and volume defects 3-123.5. Crystallinity and polymeric materials 3-133.6. Thermal transitions of crystalline and non-crystalline materials 3-183.7. Techniques: Introduction to Thermal Analysis 3-263.8. Summary 3-303.9. Problems 3-323.10. Tables 3-353.11. Figures 3-383.12. References 3-633.13. Additional reading 3-64Chapter 4: Mechanical Properties of Biomaterials 4-14.1. Introduction: Modes of mechanical testing 4-34.2. Mechanical testing methods, results and calculations 4-34.3. Fracture and failure 4-404.4. Fatigue and fatigue testing 4-434.5. Methods to improve mechanical properties 4-464.6. Techniques: Introduction to Mechanical Analysis 4-494.7. Summary 4-514.8. Problems 4-544.9. Figures 4-584.10. References 4-1014.11. Additional reading 4-101Chapter 5: Biomaterial Degradation 5-15.1. Introduction: Degradation in the biological environment 5-25.2. Corrosion/degradation of metals and ceramics 5-35.3. Degradation of polymers 5-185.4. Biodegradable materials 5-225.5. Techniques: Assays for extent of degradation 5-295.6. Summary 5-305.7. Problems 5-325.8. Tables 5-375.9. Figures 5-405.10. References 5-545.11. Additional reading 5-55Chapter 6: Biomaterial Processing 6-16.1. Introduction: Importance of biomaterials processing 6-26.2. Processing to improve bulk properties 6-26.3. Processing to form desired shapes 6-126.4. Processing to improve biocompatibility 6-266.5. Summary 6-306.6. Problems 6-326.7. Tables 6-346.8. Figures 6-356.9. References 6-546.10. Additional reading 6-55Chapter 7: Surface Properties of Biomaterials 7-17.1. Introduction: Concepts in surface chemistry and biology 7-27.2. Physicochemical surface modification techniques 7-67.3. Biological surface modification techniques 7-207.4. Surface properties and degradation 7-257.5. Patterning techniques for surfaces 7-257.6. Techniques: Introduction to surface characterization 7-277.7. Summary 7-467.8. Problems 7-487.9. Tables 7-537.10. Figures 7-587.11. References 7-1077.12. Additional reading 7-109Chapter 8: Protein Interactions with Biomaterials 8-18.1. Introduction: Thermodynamics of protein adsorption 8-28.2. Protein structure 8-78.3. Protein transport and adsorption kinetics 8-158.4. Reversibility of protein adsorption 8-188.5. Techniques: Assays for protein type and amount 8-228.6. Summary 8-338.7. Problems 8-358.8. Tables 8-398.9. Figures 8-428.10. References 8-748.11. Additional reading 8-75Chapter 9: Cell Interactions with Biomaterials 9-19.1. Introduction: Cell-surface interactions and cellular functions 9-29.2. Cellular structure 9-39.3. Extracellular environment 9-149.4. Cell-environment interactions affect cellular functions 9-239.5. Models of adhesion, spreading and migration 9-349.6. Techniques: Assays to determine effects of cell-material interactions 9-439.7. Summary 9-539.8. Problems 9-579.9. Tables 9-619.10. Figures 9-629.11. References 9-1139.12. Additional reading 9-115Chapter 10: Biomaterial Implantation and Acute Inflammation 10-110.1. Introduction: Overview of innate and acquired immunity 10-210.2. Clinical signs of inflammation and their causes 10-510.4. Role of other granulocytes 10-1110.5. Termination of acute inflammation 10-1610.6. Techniques: In vitro assays for inflammatory response 10-1710.7. Summary 10-2010.8. Problems 10-2210.9. Tables 10-2410.10. Figures 10-2710.11. References 10-3410.12. Additional reading 10-34Chapter 11: Wound Healing and the Presence of Biomaterials 11-111.1. Introduction: Formation of granulation tissue 11-211.2. Foreign body reaction 11-311.3. Fibrous encapsulation 11-411.4. Chronic inflammation 11-711.5. Four types of resolution 11-811.6. Repair vs. regeneration: wound healing in skin 11-911.7. Techniques: In vivo assays for inflammatory response 11-1211.8. Summary 11-2011.9. Problems 11-2211.10. Tables 11-2511.11. Figures 11-2811.12. References 11-3611.13. Additional reading 11-37Chapter 12: Immune Response to Biomaterials 12-112.1. Introduction: Overview of acquired immunity 12-212.2. Antigen presentation and lymphocyte maturation 12-412.3. B cells and antibodies 12-812.4. T cells 12-1212.5. The complement system 12-1412.6. Undesired immune responses to biomaterials 12-1912.7. Techniques: Assays for immune response 12-2512.8. Summary 12-2812.9. Problems 12-3212.10. Tables 12-3412.11. Figures 12-3512.12. References 12-5112.13. Additional reading 12-51Chapter 13: Biomaterials and Thrombosis 13-113.1. Introduction: Overview of hemostasis 13-213.2. Role of platelets 13-213.3. Coagulation cascade 13-513.4. Means of limiting clot formation 13-913.5. Role of endothelium 13-1113.6. Tests for hemocompatibility 13-1313.7. Summary 13-1813.8. Problems 13-2013.9. Tables 13-2513.10. Figures 13-2713.11. References 13-3213.12. Additional reading 13-33Chapter 14: Infection, Tumorigenesis and Calcification of Biomaterials 14-114.1. Introduction: Overview of other potential problems with biomaterials implantation 14-214.2. Infection 14-214.3. Techniques for infection experiments 14-1014.4. Tumorigenesis 14-1614.5. Techniques for tumorigenesis experiments 14-2114.6. Pathologic calcification 14-2314.7. Techniques for pathologic calcification experiments 14-2614.8. Summary 14-3014.9. Problems 14-3314.10. Figures 14-3614.11. References 14-4514.12. Additional reading 14-46List of Abbreviations Appendix I-1List of Symbols Appendix I-6Index Index

Johnna S. Temenoff and Antonios G. Mikos, co-authors of Biomaterials: The Intersection of Biology and Materials Science, have been chosen to receive the 2010 Meriam/Wiley Distinguished Author Award from the American Society for Engineering Education (ASEE). This marks the first time that authors of a biomedical engineering textbook have been recognized with this award.

• Chapter 1: Materials for Biomedical Applications 1-11.1. Introduction to biomaterials 1-21.2. Biological response to biomaterials 1-81.3. Biomaterial product testing and FDA approval 1-101.4. Types of biomaterials 1-111.5. Processing of biomaterials 1-151.6. Important properties of biomaterials 1-161.7. Principles of chemistry 1-211.8. Summary 1-351.9. Problems 1-371.10. Tables 1-391.11. Figures 1-441.12. References 1-701.13. Additional reading 1-72Chapter 2: Chemical Structure of Biomaterials 2-12.1. Introduction: Bonding and the structure of biomaterials 2-22.2. Structure of Metals 2-22.3. Structure of Ceramics 2-182.4. Structure of polymers 2-242.5. Techniques: Introduction to material characterization 2-412.6. Summary 2-622.7. Problems 2-642.8. Tables 2-692.9. Figures 2-792.10. References 2-1482.11. Additional reading 2-149Chapter 3: Physical Properties of Biomaterials 3-13.1. Introduction: From atomic groupings to bulk materials 3-23.2. Crystallinity and linear defects 3-23.3. Crystallinity and planar defects 3-83.4. Crystallinity and volume defects 3-123.5. Crystallinity and polymeric materials 3-133.6. Thermal transitions of crystalline and non-crystalline materials 3-183.7. Techniques: Introduction to Thermal Analysis 3-263.8. Summary 3-303.9. Problems 3-323.10. Tables 3-353.11. Figures 3-383.12. References 3-633.13. Additional reading 3-64Chapter 4: Mechanical Properties of Biomaterials 4-14.1. Introduction: Modes of mechanical testing 4-34.2. Mechanical testing methods, results and calculations 4-34.3. Fracture and failure 4-404.4. Fatigue and fatigue testing 4-434.5. Methods to improve mechanical properties 4-464.6. Techniques: Introduction to Mechanical Analysis 4-494.7. Summary 4-514.8. Problems 4-544.9. Figures 4-584.10. References 4-1014.11. Additional reading 4-101Chapter 5: Biomaterial Degradation 5-15.1. Introduction: Degradation in the biological environment 5-25.2. Corrosion/degradation of metals and ceramics 5-35.3. Degradation of polymers 5-185.4. Biodegradable materials 5-225.5. Techniques: Assays for extent of degradation 5-295.6. Summary 5-305.7. Problems 5-325.8. Tables 5-375.9. Figures 5-405.10. References 5-545.11. Additional reading 5-55Chapter 6: Biomaterial Processing 6-16.1. Introduction: Importance of biomaterials processing 6-26.2. Processing to improve bulk properties 6-26.3. Processing to form desired shapes 6-126.4. Processing to improve biocompatibility 6-266.5. Summary 6-306.6. Problems 6-326.7. Tables 6-346.8. Figures 6-356.9. References 6-546.10. Additional reading 6-55Chapter 7: Surface Properties of Biomaterials 7-17.1. Introduction: Concepts in surface chemistry and biology 7-27.2. Physicochemical surface modification techniques 7-67.3. Biological surface modification techniques 7-207.4. Surface properties and degradation 7-257.5. Patterning techniques for surfaces 7-257.6. Techniques: Introduction to surface characterization 7-277.7. Summary 7-467.8. Problems 7-487.9. Tables 7-537.10. Figures 7-587.11. References 7-1077.12. Additional reading 7-109Chapter 8: Protein Interactions with Biomaterials 8-18.1. Introduction: Thermodynamics of protein adsorption 8-28.2. Protein structure 8-78.3. Protein transport and adsorption kinetics 8-158.4. Reversibility of protein adsorption 8-188.5. Techniques: Assays for protein type and amount 8-228.6. Summary 8-338.7. Problems 8-358.8. Tables 8-398.9. Figures 8-428.10. References 8-748.11. Additional reading 8-75Chapter 9: Cell Interactions with Biomaterials 9-19.1. Introduction: Cell-surface interactions and cellular functions 9-29.2. Cellular structure 9-39.3. Extracellular environment 9-149.4. Cell-environment interactions affect cellular functions 9-239.5. Models of adhesion, spreading and migration 9-349.6. Techniques: Assays to determine effects of cell-material interactions 9-439.7. Summary 9-539.8. Problems 9-579.9. Tables 9-619.10. Figures 9-629.11. References 9-1139.12. Additional reading 9-115Chapter 10: Biomaterial Implantation and Acute Inflammation 10-110.1. Introduction: Overview of innate and acquired immunity 10-210.2. Clinical signs of inflammation and their causes 10-510.4. Role of other granulocytes 10-1110.5. Termination of acute inflammation 10-1610.6. Techniques: In vitro assays for inflammatory response 10-1710.7. Summary 10-2010.8. Problems 10-2210.9. Tables 10-2410.10. Figures 10-2710.11. References 10-3410.12. Additional reading 10-34Chapter 11: Wound Healing and the Presence of Biomaterials 11-111.1. Introduction: Formation of granulation tissue 11-211.2. Foreign body reaction 11-311.3. Fibrous encapsulation 11-411.4. Chronic inflammation 11-711.5. Four types of resolution 11-811.6. Repair vs. regeneration: wound healing in skin 11-911.7. Techniques: In vivo assays for inflammatory response 11-1211.8. Summary 11-2011.9. Problems 11-2211.10. Tables 11-2511.11. Figures 11-2811.12. References 11-3611.13. Additional reading 11-37Chapter 12: Immune Response to Biomaterials 12-112.1. Introduction: Overview of acquired immunity 12-212.2. Antigen presentation and lymphocyte maturation 12-412.3. B cells and antibodies 12-812.4. T cells 12-1212.5. The complement system 12-1412.6. Undesired immune responses to biomaterials 12-1912.7. Techniques: Assays for immune response 12-2512.8. Summary 12-2812.9. Problems 12-3212.10. Tables 12-3412.11. Figures 12-3512.12. References 12-5112.13. Additional reading 12-51Chapter 13: Biomaterials and Thrombosis 13-113.1. Introduction: Overview of hemostasis 13-213.2. Role of platelets 13-213.3. Coagulation cascade 13-513.4. Means of limiting clot formation 13-913.5. Role of endothelium 13-1113.6. Tests for hemocompatibility 13-1313.7. Summary 13-1813.8. Problems 13-2013.9. Tables 13-2513.10. Figures 13-2713.11. References 13-3213.12. Additional reading 13-33Chapter 14: Infection, Tumorigenesis and Calcification of Biomaterials 14-114.1. Introduction: Overview of other potential problems with biomaterials implantation 14-214.2. Infection 14-214.3. Techniques for infection experiments 14-1014.4. Tumorigenesis 14-1614.5. Techniques for tumorigenesis experiments 14-2114.6. Pathologic calcification 14-2314.7. Techniques for pathologic calcification experiments 14-2614.8. Summary 14-3014.9. Problems 14-3314.10. Figures 14-3614.11. References 14-4514.12. Additional reading 14-46List of Abbreviations Appendix I-1List of Symbols Appendix I-6Index Index

Johnna S. Temenoff and Antonios G. Mikos, co-authors of Biomaterials: The Intersection of Biology and Materials Science, have been chosen to receive the 2010 Meriam/Wiley Distinguished Author Award from the American Society for Engineering Education (ASEE). This marks the first time that authors of a biomedical engineering textbook have been recognized with this award.

• Chapter 1: Materials for Biomedical Applications 1-11.1. Introduction to biomaterials 1-21.2. Biological response to biomaterials 1-81.3. Biomaterial product testing and FDA approval 1-101.4. Types of biomaterials 1-111.5. Processing of biomaterials 1-151.6. Important properties of biomaterials 1-161.7. Principles of chemistry 1-211.8. Summary 1-351.9. Problems 1-371.10. Tables 1-391.11. Figures 1-441.12. References 1-701.13. Additional reading 1-72Chapter 2: Chemical Structure of Biomaterials 2-12.1. Introduction: Bonding and the structure of biomaterials 2-22.2. Structure of Metals 2-22.3. Structure of Ceramics 2-182.4. Structure of polymers 2-242.5. Techniques: Introduction to material characterization 2-412.6. Summary 2-622.7. Problems 2-642.8. Tables 2-692.9. Figures 2-792.10. References 2-1482.11. Additional reading 2-149Chapter 3: Physical Properties of Biomaterials 3-13.1. Introduction: From atomic groupings to bulk materials 3-23.2. Crystallinity and linear defects 3-23.3. Crystallinity and planar defects 3-83.4. Crystallinity and volume defects 3-123.5. Crystallinity and polymeric materials 3-133.6. Thermal transitions of crystalline and non-crystalline materials 3-183.7. Techniques: Introduction to Thermal Analysis 3-263.8. Summary 3-303.9. Problems 3-323.10. Tables 3-353.11. Figures 3-383.12. References 3-633.13. Additional reading 3-64Chapter 4: Mechanical Properties of Biomaterials 4-14.1. Introduction: Modes of mechanical testing 4-34.2. Mechanical testing methods, results and calculations 4-34.3. Fracture and failure 4-404.4. Fatigue and fatigue testing 4-434.5. Methods to improve mechanical properties 4-464.6. Techniques: Introduction to Mechanical Analysis 4-494.7. Summary 4-514.8. Problems 4-544.9. Figures 4-584.10. References 4-1014.11. Additional reading 4-101Chapter 5: Biomaterial Degradation 5-15.1. Introduction: Degradation in the biological environment 5-25.2. Corrosion/degradation of metals and ceramics 5-35.3. Degradation of polymers 5-185.4. Biodegradable materials 5-225.5. Techniques: Assays for extent of degradation 5-295.6. Summary 5-305.7. Problems 5-325.8. Tables 5-375.9. Figures 5-405.10. References 5-545.11. Additional reading 5-55Chapter 6: Biomaterial Processing 6-16.1. Introduction: Importance of biomaterials processing 6-26.2. Processing to improve bulk properties 6-26.3. Processing to form desired shapes 6-126.4. Processing to improve biocompatibility 6-266.5. Summary 6-306.6. Problems 6-326.7. Tables 6-346.8. Figures 6-356.9. References 6-546.10. Additional reading 6-55Chapter 7: Surface Properties of Biomaterials 7-17.1. Introduction: Concepts in surface chemistry and biology 7-27.2. Physicochemical surface modification techniques 7-67.3. Biological surface modification techniques 7-207.4. Surface properties and degradation 7-257.5. Patterning techniques for surfaces 7-257.6. Techniques: Introduction to surface characterization 7-277.7. Summary 7-467.8. Problems 7-487.9. Tables 7-537.10. Figures 7-587.11. References 7-1077.12. Additional reading 7-109Chapter 8: Protein Interactions with Biomaterials 8-18.1. Introduction: Thermodynamics of protein adsorption 8-28.2. Protein structure 8-78.3. Protein transport and adsorption kinetics 8-158.4. Reversibility of protein adsorption 8-188.5. Techniques: Assays for protein type and amount 8-228.6. Summary 8-338.7. Problems 8-358.8. Tables 8-398.9. Figures 8-428.10. References 8-748.11. Additional reading 8-75Chapter 9: Cell Interactions with Biomaterials 9-19.1. Introduction: Cell-surface interactions and cellular functions 9-29.2. Cellular structure 9-39.3. Extracellular environment 9-149.4. Cell-environment interactions affect cellular functions 9-239.5. Models of adhesion, spreading and migration 9-349.6. Techniques: Assays to determine effects of cell-material interactions 9-439.7. Summary 9-539.8. Problems 9-579.9. Tables 9-619.10. Figures 9-629.11. References 9-1139.12. Additional reading 9-115Chapter 10: Biomaterial Implantation and Acute Inflammation 10-110.1. Introduction: Overview of innate and acquired immunity 10-210.2. Clinical signs of inflammation and their causes 10-510.4. Role of other granulocytes 10-1110.5. Termination of acute inflammation 10-1610.6. Techniques: In vitro assays for inflammatory response 10-1710.7. Summary 10-2010.8. Problems 10-2210.9. Tables 10-2410.10. Figures 10-2710.11. References 10-3410.12. Additional reading 10-34Chapter 11: Wound Healing and the Presence of Biomaterials 11-111.1. Introduction: Formation of granulation tissue 11-211.2. Foreign body reaction 11-311.3. Fibrous encapsulation 11-411.4. Chronic inflammation 11-711.5. Four types of resolution 11-811.6. Repair vs. regeneration: wound healing in skin 11-911.7. Techniques: In vivo assays for inflammatory response 11-1211.8. Summary 11-2011.9. Problems 11-2211.10. Tables 11-2511.11. Figures 11-2811.12. References 11-3611.13. Additional reading 11-37Chapter 12: Immune Response to Biomaterials 12-112.1. Introduction: Overview of acquired immunity 12-212.2. Antigen presentation and lymphocyte maturation 12-412.3. B cells and antibodies 12-812.4. T cells 12-1212.5. The complement system 12-1412.6. Undesired immune responses to biomaterials 12-1912.7. Techniques: Assays for immune response 12-2512.8. Summary 12-2812.9. Problems 12-3212.10. Tables 12-3412.11. Figures 12-3512.12. References 12-5112.13. Additional reading 12-51Chapter 13: Biomaterials and Thrombosis 13-113.1. Introduction: Overview of hemostasis 13-213.2. Role of platelets 13-213.3. Coagulation cascade 13-513.4. Means of limiting clot formation 13-913.5. Role of endothelium 13-1113.6. Tests for hemocompatibility 13-1313.7. Summary 13-1813.8. Problems 13-2013.9. Tables 13-2513.10. Figures 13-2713.11. References 13-3213.12. Additional reading 13-33Chapter 14: Infection, Tumorigenesis and Calcification of Biomaterials 14-114.1. Introduction: Overview of other potential problems with biomaterials implantation 14-214.2. Infection 14-214.3. Techniques for infection experiments 14-1014.4. Tumorigenesis 14-1614.5. Techniques for tumorigenesis experiments 14-2114.6. Pathologic calcification 14-2314.7. Techniques for pathologic calcification experiments 14-2614.8. Summary 14-3014.9. Problems 14-3314.10. Figures 14-3614.11. References 14-4514.12. Additional reading 14-46List of Abbreviations Appendix I-1List of Symbols Appendix I-6Index Index