Biomaterials for Organ and Tissue Regeneration

New Technologies and Future Prospects

Häftad, Engelska, 2020

Av Vrana,Niha, Nihal Vrana, Helena Knopf-Marques, Julien Barthes, France) Vrana, Nihal (Co-founder and CEO of SPARTHA Medical, Strasbourg, France, and Affiliated Researcher at the University of Strasbourg, PROTiP Medical) Knopf-Marques, Helena (Senior Researcher, PROTiP Medical) Barthes, Julien (Project Manager

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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations.

Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities
Encompasses the classic paradigm of tissue engineering for creation of new functional tissue
Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Produktinformation

Utgivningsdatum2020-03-19
Mått152 x 229 x undefined mm
Vikt1 480 g
FormatHäftad
SpråkEngelska
SerieWoodhead Publishing Series in Biomaterials
Antal sidor846
FörlagElsevier Science
ISBN9780081029060

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Nihal Vrana is Co-founder of SPARTHA Medical. He holds B.Sc. (Biology) and M.Sc. (Biotechnology) degrees from Middle East Technical University. He obtained his PhD at Dublin City University as a Marie Curie ESR fellow. His major research interests are titanium and silicone implants, tissue engineering, cell encapsulation, antimicrobial surfaces, multifunctional coatings, immunomodulation, real-time monitoring of implants, biomaterial risk assessment and cell biomaterials interactions. He has coordinated 2 multi-partner, multinational EU projects (BiMot and IMMODGEL (www.immodgel.com)) and is currently coordinating a H2020 project (PANBioRA, www.panbiora.eu). Helena Knopf-Marques is a Senior Researcher at PROTiP Medical. She has also been associate professor at Strasbourg University. She has been working with the development of new biomaterials since her graduation. She is a Chemical Engineer with a masters in Mechanical Engineering. She received her PhD from the Program in Metallurgical and Materials Engineering at Federal University of Rio de Janeiro. Her main research interests are tissue engineering, multifunctional coatings, immunomodulation of biomaterial surfaces, 3D printing and cell biomaterial interactions. She is presently working on the EU Horizon 2020 project PANBioRA that aims to develop new instruments for biomaterials characterization and risk assessment. Dr. Julien Barthes is collaborative Project Manager at PROTiP MEDICAL. He holds two master’s degrees in physical/chemical properties of polymers and in polymer science (ECPM, Strasbourg). He obtained in PhD in 2014 at Strasbourg in Inserm (French National Institute of Health and Medical Research) in “Biomaterials and Bioengineering department His main research areas are hydrogel development, titanium implants, tissue engineering, cell biomaterials interactions, release of bioactive molecules in cell microenvironment and 3D printing. He is a scientific contributor in Horizon 2020European Project (PANBioRA) about biomaterial risk assessment. He is also in charge of the development of patient specific 3D printed medical implant from bench to market.

1. IntroductionSection 1: Biomaterials2. Classes of Biomaterials used in Tissue/Organ Regeneration3. Physicochemical Properties of Biomaterials4. Synthesis or Modification of Biomaterials for Regenerative Medicine Applications5. Surface Modifications of Biomaterials for Tissue EngineeringSection 2: Cell microenvironment and signalling 6. Cell microenvironment and ECM7. Cell signalling and strategies to modulate cell behaviourSection 3: Cells8. Stem cells: sources, properties and cell types9. Tissue specific cells: sources, properties and cell types10. Cell differentiation: sources, properties and cell types11. Immune cells: sources, properties and cell types12. Angiogenesis/vascular cells: sources, properties and cell typesSection 4: Organ specific Artificial tissues/Organs13. Heart/Cardiovascular tissues14. Respiratory system tissues 15. Digestive system tissues16. Kidney Tissue Engineering17. Liver Tissue Engineering18. Pancreas Tissue Engineering 19. Neural Tissue Engineering20. Musculoskeletal Tissue engineeringSection 5: Biotechnological approaches and Enabling technologies related to organ regeneration21. Emerging biotechnological approaches with respect to organ regeneration: SiRNA, miRNA, CRISPR, CAR-T therapy, -omics approaches etc.22. Bioreactors23. On-chip organ systems24. In vitro disease and organ models25. Bioprinting26. Biorobotics27. Imaging techniques for biomaterials, stem cells and engineered tissues/organs28. Future perspectives/Industrialisation and Up-scaling of organ regeneration technologies