Biomaterials Effect on the Bone Microenvironment

Fabrication, Regeneration, and Clinical Applications

Inbunden, Engelska, 2023

AvJiacan Su,Jiacan Su,Xiao Chen,Yingying Jing,China) Su, Jiacan (Shanghai University,China) Chen, Xiao (Shanghai Changhai Hospital,China) Jing, Yingying (Shanghai University

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Biomaterials Effect on the Bone Microenvironment Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation. The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect. Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as: Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironmentRelationship between biological factors of various materials and physiological functions in bone microenvironmentApplication of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironmentEmerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regenerationFuture outlook of bone tissue engineering along with the general process of bone remodeling and regenerationWith comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.

Produktinformation

Utgivningsdatum2023-02-08
Mått170 x 244 x 16 mm
Vikt567 g
FormatInbunden
SpråkEngelska
Antal sidor208
FörlagWiley-VCH Verlag GmbH
ISBN9783527350438

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Jiacan Su is the Department Head of Institute of Translational Medicine, Shanghai University, Shanghai and chief physician of Orthopedics Department, Shanghai Changhai Hospital, Second Military Medical University, Shanghai. Professor Su received his bachelor’s degree (1999) and M.D. (2004) from Second Military Medical University.Xiao Chen, Associate Professor, Department of Orthopedics, Shanghai Changhai Hospital, China.Yingying Jing, Assistant Professor, Institute of Translational Medicine, Shanghai University, China.

Preface ix1 Bone Microenvironment 1Yingying Jing and Xiao Chen1.1 Introduction 11.2 Bone Microenvironment and Diseases 91.3 Biomaterials and Bone Microenvironment 182 Materiobiological Effects Regulate the Bone Microenvironment 43Shuangshuang Chen2.1 Bioactive Components Influence the Bone Microenvironment 442.2 Physicochemical Property Influence the Bone Microenvironment 593 Design and Application of Biomaterials to Regulate Microenvironment for Bone Regeneration 75Xiuhui Wang and Yingying Jiang3.1 Natural Biomaterials for Bone Microenvironment Regulation 763.2 Synthetic Biomaterials for Bone Microenvironment Regulation 874 Fabrication Technologies of Biomaterials 107Qin Zhang and Xue Xu4.1 Fabrication Technologies of Biomaterials 1074.2 Fabrication Technologies of Hydrogels 1144.3 Fabrication Technologies of Other Biomaterials 121References 1255 Mechanisms for Biomaterials Reconstruct Microenvironment in Bone Regeneration 129Yan Wei and Mengmeng Li5.1 Mechanical Support Effect 1295.2 Redox Effect 1335.3 Pro-angiogenesis Effect 1385.4 Inflammatory Immune Effect 1445.5 Anti-Aging Effect 1496 Biomaterials Regulating Bone Microenvironment in Clinical Application 157Zhen Geng, Xiaoxiang Ren, and Sicheng Wang6.1 Introduction 1576.2 Autogenous Bone Remodeling 1586.3 Allogeneic Bone Regeneration 1616.4 Clinical Effect of Biomaterials 1656.4.1 Bone tissue engineering 1686.5 Clinical Challenges and Opportunities 169References 1707 Conclusions and Perspectives 175Ke Xu, Yan Hu, and Han Liu7.1 Bone Microenvironment Under Physiological and Pathological Conditions 1757.2 Biological Effects Under Modulation of Materials 1777.3 Design and Application of Biomaterials in Bone Regeneration 1787.4 Fabrication Technologies 1807.5 Microenvironment Under Biomaterial Regulation 1817.6 Biomaterials in Clinical Experience 182Index 185