Biomarkers in Kidney Transplantation

Dr. Smita Pattanaik is a physician-scientist involved in teaching postgraduate students of clinical pharmacology and clinical patient care services, focusing on the delivery of precision medicine in clinics through therapeutic drug monitoring, pharmacogenomics, and model-informed precision dosing. Her research group, the Translational Pharmacology Laboratory, comprises clinicians, clinical scientists, and basic scientists. The goal is bedside-to-bench and bench-to-bedside translation involving immunosuppressant drugs (ISDs), the repositioning of drugs as anticancer agents, and collaborative clinical trials. Most of the current projects focus on organ transplantation, autoimmune diseases, and cancer. Ashish Sharma is a highly experienced transplant surgeon. He has more than 200 publications in national and international journals. He has been instrumental in starting academic training programs in kidney and pancreas transplant at PGIMER. Under his leadership, the department has been able to establish a pancreas transplant program, donation after cardiac death, along with a comprehensive surveillance and interventional vascular access program. He has been awarded by the Ministry of Health and the Indian Society of Organ Transplant for his exemplary services in transplant.

• 1. Organ transplantation: past, present, and future2. Trends in kidney transplantation3. Immunobiology in kidney transplantation4. Immunosuppression in kidney transplantation5. Challenges in the therapeutic drug monitoring of immunosuppressants6. Overview of biomarkers in kidney transplantation7. Biomarkers for ischemia reperfusion injury and delayed graft function8. Biomarkers of renal transplant rejection: yesterday, today, and tomorrow9. Biomarkers predicting the response to immunosuppressant therapy10. Biomarkers of recurrent disease after kidney transplantation11. Biomarkers of tolerance in renal transplantation12. Biomarkers for detecting opportunistic infections in renal transplant recipients13. Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs14. Biomarkers for drug development in kidney transplantation15. Commercially available biomarker tests in kidney transplantation16. The unmet needs, current challenges and future directions for biomarkers in renal transplantation