Biology of Archaea 2

Molecular Biology of Archaea, From Genome Maintenance to the Regulation of Gene Expression

Inbunden, Engelska, 2025

AvBéatrice Clouet-d'Orval,Béatrice Clouet-d'Orval,Bruno Franzetti,Philippe Oger

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Archaea constitute a new branch of life alongside bacteria and eukaryotes. These microorganisms are unique in their cellular and molecular aspects. They have evolutionary links with the first eukaryotic cells and are now being used to elucidate fundamental biological questions.Champions of extremophilicity, archaea are helping to lift the veil on the limits of life on Earth. Biology of Archaea 2 presents the diverse molecular mechanisms involved in the fundamental processes of genome maintenance and regulation of gene expression in archaeal cells.This book analyzes the complex machinery involved in chromosome replication, DNA repair, RNA synthesis (transcription) and protein synthesis (translation), and explores the different classes of RNAs and enzymes involved in RNA maturation and degradation. These regulate the stability of messenger and regulatory non-coding RNAs, and contribute to the formation of the mature forms of ribosomal RNAs and transfer RNAs. These molecular mechanisms are closely related to those of eukaryotes.

Produktinformation

Utgivningsdatum2025-07-08
Mått156 x 234 x 16 mm
Vikt531 g
FormatInbunden
SpråkEngelska
SerieISTE Invoiced
Antal sidor256
FörlagISTE Ltd
ISBN9781789451696

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Biologi inom Naturvetenskap och teknik

Béatrice Clouet-d’Orval is Research Director at the CNRS and works at the Center for Integrative Biology, Toulouse, France. Her main research areas focus on the post-transcriptional regulation of gene expression.Bruno Franzetti is Research Director at the CNRS, France, where he specializes in the structural biology of archaea. His research areas include biophysical and cellular mechanisms that maintain proteome integrity under extreme conditions.Philippe Oger is Research Director at the CNRS, France. His research areas include understanding the adaptations of prokaryotes in response to extreme conditions, using a multidisciplinary approach combining the methods derived from atomic physics and cutting-edge molecular biology and modeling.

Preface xiBéatrice CLOUET-D'ORVAL, Bruno FRANZETTI and Philippe OGERChapter 1. Replication of Archaeal Chromosomes 1Ghislaine HENNEKE, Roxane LESTINI, Marc NADAL and Didier FLAMENT1.1. Replication initiation 21.2. The elongation phase of replication 81.3. Okazaki fragment maturation 101.4. Restarting replication forks 151.5. Replication termination 181.6. Chromosome segregation and decatenation 181.7. References 19Chapter 2. Archaeal DNA Repair 25Caroline L'HERMITTE-STEAD, Anaïs BAYARD, Alexey ALEKSANDROV, Roxane LESTINI and Hannu MYLLYKALLIO2.1. General introduction 252.2. Several different types of DNA damages occur in archaea 282.3. Different archaeal DNA repair pathways 312.4. Coordination of the different pathways by the replication clamp 402.5. Summary and conclusion 422.6. References 43Chapter 3. Transcription in Archaea 45Thomas FOUQUEAU, Duy KHANH PHUNG and Ludovic SAUGUET3.1. RNA polymerase 473.2. The three stages of transcription 513.3. Transcription regulation 643.4. References 66Chapter 4. RNA Classes and Their Maturation and Degradation Enzymes 77Manon BATISTA, Béatrice CLOUET-D'ORVAL and Marie BOUVIER4.1. Introduction 774.2. RNA classes in archaea 794.3. Ribonuclease families in archaea 844.4. Ubiquitous RNA-binding proteins in archaea 954.5. Conclusion 1004.6. References 100Chapter 5. Ribosome and Transfer RNA Biogenesis 115Tamara BASTA and Sébastien FERREIRA-CERCA5.1. Ribosome biogenesis 1165.2. Synthesis and maturation of tRNAs 1335.3. Methodical toolboxes 1565.4. References 158Chapter 6. The Diversity and Function of Noncoding RNAs in Archaea 167Hubert F. BECKER and Christine GASPIN6.1. Introduction 1676.2. Noncoding RNA diversity 1686.3. ncRNA identification 1786.4. Circularization of noncoding RNAs 1826.5. Conclusion 1856.6. References 186Chapter 7. Translation in Archaea 193Emmanuelle SCHMITT and Yves MECHULAM7.1. Initiating the translation 1957.2. Elongation peptide synthesis 2067.3. Translation termination and ribosome recycling 2147.4. Conclusion 2197.5. References 220List of Authors 233Index 237