This book constitutes the refereed proceedings of the 10th International Conference on Bioinspired Optimization Methods and Their Applications, BIOMA 2022, held in Maribor, Slovenia, in November 2022.The 19 full papers presented in this book were carefully reviewed and selected from 23 submissions.The papers in this BIOMA proceedings specialized in bioinspired algorithms as a means for solving the optimization problems and came in two categories: theoretical studies and methodology advancements on the one hand, and algorithm adjustments and their applications on the other.