Biochemistry, International Adaptation

Donald Voet received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel.Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.

• Guide to Media Resources xviPart I Introduction and background 1Chapter 1 Life 31. The Origin of Life 32. Evolution of Cells 93. Biochemistry: A Prologue 184. Genetics: An Overview 23Chapter 2 Aqueous Solutions and Bioenergetics 361. Properties of Water 372. Acids, Bases, and Buffers 403. First Law of Thermodynamics: Energy is Conserved 454. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder 465. Chemical Equilibria 49Appendix: Concentration Dependence of Free Energy 52Part II Biomolecules 57Chapter 3 Amino Acids 591. The Amino Acids of Proteins 592. Stereochemistry of Amino Acids 643. Chemical Properties of Amino Acids 694. "Nonstandard" Amino Acids 71Chapter 4 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 751. Nucleotides and Nucleic Acids 762. DNA Is the Carrier of Genetic Information 783. Double Helical DNA 814. Forces Stabilizing Nucleic Acid Structures 955. Supercoiled DNA 1016. Gene Expression and Replication: An Overview 1137. Molecular Cloning 122Chapter 5 Techniques of Protein and Nucleic Acid Purification 1501. Protein Isolation 1502. Protein Solubility 1543. Chromatographic Separations 1564. Electrophoresis 1675. Ultracentrifugation 1736. Nucleic Acid Fractionation 178Chapter 6 Covalent Structures of Proteins and Nucleic Acids 1841. Primary Structure Determination of Proteins 1852. Chemical Synthesis of Polypeptides 1963. Nucleic Acid Sequencing 2014. Chemical Synthesis of Oligonucleotides 2105. Chemical Evolution 2146. Bioinformatics: An Introduction 223Chapter 7 Three-Dimensional Structures of Proteins 2411. Secondary Structure 2412. Fibrous Proteins 2533. Globular Proteins 2604. Protein Stability 2805. Quaternary Structure 288Appendix: Viewing Stereo Pictures 292Chapter 8 Protein Folding, Dynamics, and Structural Evolution 3001. Protein Folding: Theory and Experiment 3002. Folding Accessory Proteins 3123. Protein Structure Prediction and Design 3244. Protein Dynamics 3285. Conformational Diseases: Amyloid and Prions 3316. Structural Evolution 338Chapter 9 Chemical and Biological Aspects of Hemoglobin 3461. Hemoglobin and Myoglobin Function 3462. Structure and Mechanism 3553. Abnormal Hemoglobins 3644. Allosteric Regulation 371Appendix: Derivations of Symmetry Model Equations 377Chapter 10 Sugars and Polysaccharides 3821. Monosaccharides 3822. Polysaccharides 3883. Glycoproteins 396Chapter 11 Lipids and Membranes 4091. Lipid Classification 4092. Lipid Aggregates and their Properties 4163. Biological Membranes 4214. Membrane Assembly and Protein Targeting 4405. Lipoproteins 468Part III MECHANISMS OF ENZYME ACTION 485Chapter 12 Enzyme Kinetics 4871. Historical Perspective 4882. Substrate Specificity 4893. Coenzymes 4924. Control of Enzymatic Activity 4935. A Primer of Enzyme Nomenclature 4986. Chemical Kinetics 4987. Enzyme Kinetics 5038. Inhibition 5089. Effects of pH 51210. Bisubstrate Reactions 513Appendix: Derivations of Michaelis-Menten Equation Variants 516Chapter 13 Enzymatic Catalysis and Drug Design 5231. Catalytic Mechanisms 5232. Lysozyme 5343. Serine Proteases 5414. Drug Design 553Part IV METABOLISM 573Chapter 14 Introduction to Metabolism 5751. Metabolic Pathways 5762. Organic Reaction Mechanisms 5793. Experimental Approaches to the Study of Metabolism 5854. Thermodynamics of Phosphate Compounds 5945. Oxidation-Reduction Reactions 6006. Thermodynamics of Life 603Chapter 15 Glycolysis and Other Related Pathways 6091. The Glycolytic Pathway 6102. The Reactions of Glycolysis 6133. Fermentation: The Anaerobic Fate of Pyruvate 6304. Metabolic Regulation and Control 6355. Metabolism of Hexoses Other Than Glucose 6466. The Pentose Phosphate Pathway 6497. Gluconeogenesis 6558. Biosynthesis of Oligosaccharides and Glycoproteins 664Chapter 16 Glycogen Metabolism 6821. Glycogen Breakdown 6832. Glycogen Synthesis 6883. Control of Glycogen Metabolism 6914. Glycogen Storage Diseases 710Chapter 17 Signal Transduction 7151. Hormones 7152. Heterotrimeric G Proteins 7323. Tyrosine Kinase-Based Signaling 7434. The Phosphoinositide Cascade 768Chapter 18 Transport through Membranes 7881. Thermodynamics of Transport 7882. Kinetics and Mechanisms of Transport 7893. ATP-Driven Active Transport 8024. Ion Gradient-Driven Active Transport 8125. Neurotransmission 816Chapter 19 Citric Acid Cycle 8331. Cycle Overview 8332. Metabolic Sources of Acetyl-Coenzyme A 8363. Enzymes of the Citric Acid Cycle 8504. Regulation of the Citric Acid Cycle 8585. The Amphibolic Nature of the Citric Acid Cycle 8616. The Glyoxylate Cycle 862Chapter 20 Electron Transport and Oxidative Phosphorylation 8681. The Mitochondrion 8692. Electron Transport 8733. Oxidative Phosphorylation 8904. Control of ATP Production 907Chapter 21 Photosynthesis: Bioinorganic Chemistry and Physiology 9161. Chloroplasts 9172. Light Reactions 9183. Dark Reactions 942Chapter 22 Lipid Metabolism 9561. Lipid Digestion, Absorption, and Transport 9562. Fatty Acid Oxidation 9613. Ketone Bodies 9764. Fatty Acid Biosynthesis 9815. Regulation of Fatty Acid Metabolism 9926. Cholesterol Metabolism 9947. Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins 10128. Phospholipid and Glycolipid Metabolism 10239. Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight 1033Chapter 23 Amino Acid Metabolism 10451. Amino Acid Deamination 10462. Metabolic Breakdown of Individual Amino Acids 10513. The Urea Cycle 10694. Amino Acids as Biosynthetic Precursors 10735. Amino Acid Biosynthesis 1091Chapter 24 Nucleotide Metabolism 11101. Synthesis of Purine Ribonucleotides 11102. Synthesis of Pyrimidine Ribonucleotides 11183. Formation of Deoxyribonucleotides 11224. Nucleotide Degradation 11335. Biosynthesis of Nucleotide Coenzymes 1139Part V Expression and Transmission of Genetic Information 1147Chapter 25 D NA Replication, Repair, and Recombination 11491. DNA Replication: An Overview 11492. Enzymes of Replication 11523. Prokaryotic Replication 11654. Eukaryotic Replication 11775. Repair of DNA 11896. Recombination and Mobile Genetic Elements 12017. DNA Methylation and Trinucleotide Repeat Expansions 1222Chapter 26 Transcription 12361. The Role of RNA in Protein Synthesis 12372. RNA Polymerase 12413. Control of Transcription in Prokaryotes 12594. Post-Transcriptional Processing 1277Chapter 27 Translation 13141. The Genetic Code 13142. Transfer RNA and Its Aminoacylation 13213. Ribosomes and Polypeptide Synthesis 13384. Control of Eukaryotic Translation 13745. Post-Translational Modification 1379*Chapter 28 Eukaryotic Gene Expression W-11. Chromosome Structure W-12. Genomic Organization W-123. Control of Expression W-254. Cell Differentiation and Growth W-59*Chapter 29 Viruses: Paradigms for Cellular Functions W-841. Tobacco Mosaic Virus W-862. Icosahedral Viruses W-913. Bacteriophage Lambda W-1034. Influenza Virus W-123*Chapter 30 Molecular Physiology W-1361. Blood Clotting W-1362. Immunity W-1503. Motility: Muscles, Vesicle Transport, Cilia, and Flagella W-182Index I-1*Chapters 28, 29 and 30 are available on our book companion website, www.wiley.com/college/voet.