Anthony B. Brennan is the Margaret A. Ross Endowed Professor of Materials Science and Engineering and a professor of Biomedical Engineering at the University of Florida.  He received his Bachelor's degree in chemistry from State University of New York at Potsdam in 1975 and his Ph.D. in Materials Engineering Science from Virginia Polytechnic Institute and Statue University in 1990.  Dr. Brennan has been a member of the faculty at the University of Florida since 1991.  His materials focus is on the structure of the interphase between the cell and the substrate.Chelsea M. Kirschner obtained a Bachelor's degree in Materials Science and Engineering at the University of Florida in 2006, and her Ph.D. in Biomedical Engineering from the University of Florida in 2010.  Dr. Kirschner completed a postdoctoral research fellowship at the University of Colorado at Boulder in 2013.  Her research focused on the influence of spatially and temporally patterned hydrogel architectures and chemistries on adult stem cell shape and differentiation. She is currently a Biomedical R&D Engineer at Sharklet Technologies in Aurora, CO.

• Contributors viiPreface xiIntroduction 1Sang Jin Lee and Anthony AtalaPart I Engineering Bio-Inspired Material Microenvironments 5Chapter 1 ECM-Inspired Chemical Cues: Biomimetic Molecules and Techniques of Immobilization 7Roger Y. Tam, Shawn C. Owen, and Molly S. ShoichetChapter 2 Dynamic Materials Mimic Developmental and Disease Changes in Tissues 25Matthew G. Ondeck and Adam J. EnglerChapter 3 The Role of Mechanical Cues in Regulating Cellular Activities and Guiding Tissue Development 45Liming BianChapter 4 Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes 59Menekse Ermis, Erkan Türker Baran, Tuğba Dursun, Ezgi Antmen, and Vasif HasirciChapter 5 Cellular Responses to Bio-Inspired Engineered Topography 77Chelsea M. Kirschner, James F. Schumacher, and Anthony B. BrennanChapter 6 Engineering The Mechanical and Growth Factor Signaling Roles of Fibronectin Fibrils 99Christopher A. LemmonChapter 7 Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing 111Elizabeth W. Kollar, Christopher L. Dearth, and Stephen F. BadylakChapter 8 Bio-Inspired Integration of Natural Materials 125Albino Martins, Marta Alves da Silva, Ana Costa-Pinto, Rui L. Reis, and Nuno M. NevesPart II Bio-Inspired Tissue Engineering 151Chapter 9 Bio-Inspired Design of Skin Replacement Therapies 153Dennis P. OrgillChapter 10 Epithelial Engineering: From Sheets to Branched Tubes 161Hye Young Kim and Celeste M. NelsonChapter 11 A Biomimetic Approach Toward The Fabrication of Epithelial-Like Tissue 175Hongjun Wang and Meng XuChapter 12 Nano- and Microstructured ECM and Biomimetic Scaffolds for Cardiac Tissue Engineering 195Quentin Jallerat, John M. Szymanski, and Adam W. FeinbergChapter 13 Strategies and Challenges for Bio-Inspired Cardiovascular Biomaterials 227Elaine L. Lee and Joyce Y. WongChapter 14 Evaluation of Bio-Inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells 259Liisa T. Kuhn, Emily Jacobs, and A. Jon GoldbergChapter 15 Learning from Tissue Equivalents: Biomechanics and Mechanobiology 281David D. Simon and Jay D. HumphreyChapter 16 Mimicking the Hematopoietic Stem Cell Niche by Biomaterials 309Eike Müller, Michael Ansorge, Carsten Werner, and Tilo PompeChapter 17 Engineering Immune Responses to Allografts 327Anthony W. Frei and Cherie L. StablerChapter 18 Immunomimetic Materials 357Jamal S. Lewis and Benjamin G. KeselowskyIndex 371

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Anthony B. Brennan is the Margaret A. Ross Endowed Professor of Materials Science and Engineering and a professor of Biomedical Engineering at the University of Florida.  He received his Bachelor's degree in chemistry from State University of New York at Potsdam in 1975 and his Ph.D. in Materials Engineering Science from Virginia Polytechnic Institute and Statue University in 1990.  Dr. Brennan has been a member of the faculty at the University of Florida since 1991.  His materials focus is on the structure of the interphase between the cell and the substrate.Chelsea M. Kirschner obtained a Bachelor's degree in Materials Science and Engineering at the University of Florida in 2006, and her Ph.D. in Biomedical Engineering from the University of Florida in 2010.  Dr. Kirschner completed a postdoctoral research fellowship at the University of Colorado at Boulder in 2013.  Her research focused on the influence of spatially and temporally patterned hydrogel architectures and chemistries on adult stem cell shape and differentiation. She is currently a Biomedical R&D Engineer at Sharklet Technologies in Aurora, CO.

• Contributors viiPreface xiIntroduction 1Sang Jin Lee and Anthony AtalaPart I Engineering Bio-Inspired Material Microenvironments 5Chapter 1 ECM-Inspired Chemical Cues: Biomimetic Molecules and Techniques of Immobilization 7Roger Y. Tam, Shawn C. Owen, and Molly S. ShoichetChapter 2 Dynamic Materials Mimic Developmental and Disease Changes in Tissues 25Matthew G. Ondeck and Adam J. EnglerChapter 3 The Role of Mechanical Cues in Regulating Cellular Activities and Guiding Tissue Development 45Liming BianChapter 4 Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes 59Menekse Ermis, Erkan Türker Baran, Tuğba Dursun, Ezgi Antmen, and Vasif HasirciChapter 5 Cellular Responses to Bio-Inspired Engineered Topography 77Chelsea M. Kirschner, James F. Schumacher, and Anthony B. BrennanChapter 6 Engineering The Mechanical and Growth Factor Signaling Roles of Fibronectin Fibrils 99Christopher A. LemmonChapter 7 Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing 111Elizabeth W. Kollar, Christopher L. Dearth, and Stephen F. BadylakChapter 8 Bio-Inspired Integration of Natural Materials 125Albino Martins, Marta Alves da Silva, Ana Costa-Pinto, Rui L. Reis, and Nuno M. NevesPart II Bio-Inspired Tissue Engineering 151Chapter 9 Bio-Inspired Design of Skin Replacement Therapies 153Dennis P. OrgillChapter 10 Epithelial Engineering: From Sheets to Branched Tubes 161Hye Young Kim and Celeste M. NelsonChapter 11 A Biomimetic Approach Toward The Fabrication of Epithelial-Like Tissue 175Hongjun Wang and Meng XuChapter 12 Nano- and Microstructured ECM and Biomimetic Scaffolds for Cardiac Tissue Engineering 195Quentin Jallerat, John M. Szymanski, and Adam W. FeinbergChapter 13 Strategies and Challenges for Bio-Inspired Cardiovascular Biomaterials 227Elaine L. Lee and Joyce Y. WongChapter 14 Evaluation of Bio-Inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells 259Liisa T. Kuhn, Emily Jacobs, and A. Jon GoldbergChapter 15 Learning from Tissue Equivalents: Biomechanics and Mechanobiology 281David D. Simon and Jay D. HumphreyChapter 16 Mimicking the Hematopoietic Stem Cell Niche by Biomaterials 309Eike Müller, Michael Ansorge, Carsten Werner, and Tilo PompeChapter 17 Engineering Immune Responses to Allografts 327Anthony W. Frei and Cherie L. StablerChapter 18 Immunomimetic Materials 357Jamal S. Lewis and Benjamin G. KeselowskyIndex 371

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Anthony B. Brennan is the Margaret A. Ross Endowed Professor of Materials Science and Engineering and a professor of Biomedical Engineering at the University of Florida.  He received his Bachelor's degree in chemistry from State University of New York at Potsdam in 1975 and his Ph.D. in Materials Engineering Science from Virginia Polytechnic Institute and Statue University in 1990.  Dr. Brennan has been a member of the faculty at the University of Florida since 1991.  His materials focus is on the structure of the interphase between the cell and the substrate.Chelsea M. Kirschner obtained a Bachelor's degree in Materials Science and Engineering at the University of Florida in 2006, and her Ph.D. in Biomedical Engineering from the University of Florida in 2010.  Dr. Kirschner completed a postdoctoral research fellowship at the University of Colorado at Boulder in 2013.  Her research focused on the influence of spatially and temporally patterned hydrogel architectures and chemistries on adult stem cell shape and differentiation. She is currently a Biomedical R&D Engineer at Sharklet Technologies in Aurora, CO.

• Contributors viiPreface xiIntroduction 1Sang Jin Lee and Anthony AtalaPart I Engineering Bio-Inspired Material Microenvironments 5Chapter 1 ECM-Inspired Chemical Cues: Biomimetic Molecules and Techniques of Immobilization 7Roger Y. Tam, Shawn C. Owen, and Molly S. ShoichetChapter 2 Dynamic Materials Mimic Developmental and Disease Changes in Tissues 25Matthew G. Ondeck and Adam J. EnglerChapter 3 The Role of Mechanical Cues in Regulating Cellular Activities and Guiding Tissue Development 45Liming BianChapter 4 Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes 59Menekse Ermis, Erkan Türker Baran, Tuğba Dursun, Ezgi Antmen, and Vasif HasirciChapter 5 Cellular Responses to Bio-Inspired Engineered Topography 77Chelsea M. Kirschner, James F. Schumacher, and Anthony B. BrennanChapter 6 Engineering The Mechanical and Growth Factor Signaling Roles of Fibronectin Fibrils 99Christopher A. LemmonChapter 7 Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing 111Elizabeth W. Kollar, Christopher L. Dearth, and Stephen F. BadylakChapter 8 Bio-Inspired Integration of Natural Materials 125Albino Martins, Marta Alves da Silva, Ana Costa-Pinto, Rui L. Reis, and Nuno M. NevesPart II Bio-Inspired Tissue Engineering 151Chapter 9 Bio-Inspired Design of Skin Replacement Therapies 153Dennis P. OrgillChapter 10 Epithelial Engineering: From Sheets to Branched Tubes 161Hye Young Kim and Celeste M. NelsonChapter 11 A Biomimetic Approach Toward The Fabrication of Epithelial-Like Tissue 175Hongjun Wang and Meng XuChapter 12 Nano- and Microstructured ECM and Biomimetic Scaffolds for Cardiac Tissue Engineering 195Quentin Jallerat, John M. Szymanski, and Adam W. FeinbergChapter 13 Strategies and Challenges for Bio-Inspired Cardiovascular Biomaterials 227Elaine L. Lee and Joyce Y. WongChapter 14 Evaluation of Bio-Inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells 259Liisa T. Kuhn, Emily Jacobs, and A. Jon GoldbergChapter 15 Learning from Tissue Equivalents: Biomechanics and Mechanobiology 281David D. Simon and Jay D. HumphreyChapter 16 Mimicking the Hematopoietic Stem Cell Niche by Biomaterials 309Eike Müller, Michael Ansorge, Carsten Werner, and Tilo PompeChapter 17 Engineering Immune Responses to Allografts 327Anthony W. Frei and Cherie L. StablerChapter 18 Immunomimetic Materials 357Jamal S. Lewis and Benjamin G. KeselowskyIndex 371

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