The volume LNCS 12393 constitutes the papers of the 22nd International Conference Big Data Analytics and Knowledge Discovery which will be held online in September 2020. The 15 full papers presented together with 14 short papers plus 1 position paper in this volume were carefully reviewed and selected from a total of 77 submissions.  This volume offers a wide range to following subjects on theoretical and practical aspects of big data analytics and knowledge discovery as a new generation of big data repository, data pre-processing, data mining, text mining, sequences, graph mining, and parallel processing.