Professor Emeritus of AnesthesiologyAssociate Chair for Academic Affairs and PromotionsNorthwestern University Feinberg School of MedicineChicago, Illinois Professor of Anesthesiology, Critical Care Medicine, and NeurologyDirector of Pain ResearchDivision of Pain MedicineJohns Hopkins University School of MedicineBaltimore, Maryland Edmond I Eger Professor of AnesthesiologyVice Chair, Research and Pain MedicineDepartments of Anesthesiology, Neurology, PM&R, Psychiatry and Neurological SurgeryNorthwestern University Feinberg School of MedicineChicago, IllinoisDirector, Pain Research Walter Reed National Military Medical CenterUniformed Services University of the Health SciencesBethesda, Maryland Professor, University of TorontoDirector, Comprehensive Integrated Pain ProgramStaff, Department of Anesthesia and Pain ManagementToronto Western Hospital Toronto, OntarioDr. Ariana M. Nelson is a Professor at the University of California Irvine School of Medicine, Department of Anesthesiology & Perioperative Care and is double board-certified in Anesthesiology and Pain Medicine. After graduating from the University of Michigan Medical School, she completed residency and fellowship training at Northwestern Memorial Hospital. Dr. Nelson's research interests include biomarkers of pain and intoxication, and she has both published and ongoing research studies in artificial intelligence and machine learning. She collaborated with NASA engineers in the development of Earth-independent medical operations as part of the Exploration Medical Integrated Product Team, focusing specifically on leveraging artificial intelligence to create a clinical decision support system for the austere environment of spaceflight. She currently works for Vast Space as the Medical Science Lead in their division of Space Medicine Operations.ProfessorDepartment of AnesthesiaDepartments of Surgery, Health Research Methods, Evidence, and Impact (HEI)School of Biomedical Engineering McMaster UniversityHamilton, ONCanada

• Section 1: Basic Considerations1. Anatomy and Physiology of the Pain Signaling Process2. Neurochemistry of Somatosensory and Pain Processing3. Taxonomy: Definition of Pain Terms and Chronic Pain SyndromesSection 2: Clinical Evaluation and Diagnostic Examinations4. Physical Examination of the Patient with Pain5. Pain Assessment6. Psychological Evaluation and Testing7. Diagnostic and Statistical Manual of Mental Disorders and Pain Management8. Neurophysiologic Testing for Pain9. Anatomy, Imaging and Common Pain-Generating Degenerative Pathologies of the Spine10. Determination of DisabilitySection 3: Perioperative Pain Management11. Preventive Analgesia12. Perioperative Nonopioid Infusions for Postoperative Pain Management13. Patient-Controlled Analgesia14. Intrathecal Opioid Injections for Postoperative Pain15. Epidural Opioids for Postoperative Pain16. Continuous Peripheral Nerve Blocks17. Pediatric Postoperative Pain18. Chronic Pain After SurgerySection 4: Chronic Pain Syndromes19. Migraine Headache and the Trigeminal Autonomic Cephalalgias (TAC)20. Tension-Type Headache, Chronic Tension-Type Headache, and Other Chronic Headache Types21. Postmeningeal Puncture Headache and Spontaneous Intracranial Hypotension22. Cervicogenic Headache23. Orofacial Pain24. Overview of Low Back Pain Disorders25. Myofascial Pain Syndrome26. Fibromyalgia and Centralized Pain States27. Complex Regional Pain Syndrome28. Herpes Zoster and Postherpetic Neuralgia29. Postamputation Pain30. Central Pain States31. Pelvic Pain32. Painful Peripheral Neuropathies33. Entrapment NeuropathiesSection 5: Cancer Pain and Pain in Special Situations34. Approach to Management of Cancer Pain35. Management of Pain at End of Life36. Pain Management in the Emergency Department37. Chronic Pain Management in Children and Adolescents38. Sickle Cell Pain39. Pain Management During Pregnancy and Lactation40. Pain Control in the Critically Ill Patient41. Geriatric Pain Section 6: Pharmacology and Pharmacologic Modalities42. Major Opioids and Pain Management43. Opioids Used for Mild to Moderate Pain44. The Prescription Drug Abuse Epidemic and Emerging Prescribing Guidelines45. Legal and Regulatory Issues in Pain Management46. Urine Drug Testing47. Substance Use Disorders and Detoxification48. Psychopharmacology for Pain Medicine49. Membrane Stabilizers50. Recommendations for Pharmacological Therapy of Neuropathic Pain51. Nonopioid Analgesics: NSAIDs, COX-2 Inhibitors, and Acetaminophen52. Intravenous Infusions for Refractory Cancer and Chronic Pain States53. Pharmacologic Management of Myofascial Pain54. Pharmacologic Management of CRPS55. Pharmacology for the Interventional Pain Physician56. Role of Cannabinoids in Pain ManagementSection 7: Therapeutic Interventions57. Ablative Neurosurgical Procedures for Treatment of Chronic Pain58. Physical Medicine and Rehabilitation Approaches to Pain Management59. Psychological Interventions for Chronic Pain60. Acupuncture 61. Tai Chi and Chronic PainSection 8: Interventional Techniques for Pain Management62. Interlaminar Epidural Steroid Injections for Lumbosacral Radicular Pain63. Transforaminal Epidural Steroid Injections and Selective Nerve Root Blocks64. ANTI TNF - a Drugs and DMARDs for Low Back Pain65. Facet Syndrome66. Sacroiliac Joint Syndrome67. Piriformis Syndrome68. Pulsed Radiofrequency, Water-Cooled Radiofrequency, and Cryoneurolysis69. Discography70. Vertebroplasty and Kyphoplasty71. Neurolytic Sympathetic Blocks72. Central and Peripheral Neurolysis73. Spinal Cord Stimulation74. Peripheral Nerve Stimulation75. Dorsal Root Ganglion Stimulation76. Implanted Drug Delivery Systems for the Control of Chronic Pain77. Fluoroscopy and Radiation Safety78. Efficacy of Interventional Procedures for Neuropathic PainSection 9: Other Nerve Blocks in Pain Medicine79. Ultrasound-Guided Procedures for Pain Management80. Deep Muscle Injections: Piriformis, Scalene Muscle, Iliposoas Injections81. Ultrasound-Guided Musculoskeletal Injections--Shoulder, Hip, and Knee82. Head and Neck Blocks83. Truncal Blocks: Intercostal, Paravertebral, Interpleural, Tap, Suprascapular, Ilioinguinal, and Iliohypogastric Nerve Blocks84. Sympathetic Blocks: Stellate Ganglion, Lumbar Sympathetic Blocks, and Visceral Sympathetic Blocks -- Fluoroscopy and Ultrasound-Guided85. Interventional Pain Procedures in Patients on Anticoagulants86. Interventional Pain Procedures and the Risk of Infection

Review of the previous edition: "The purpose is to provide a ready to use, comprehensive book on chronic pain management. This fourth edition successfully does that, covering all the topics one needs to know. In this age where everyone is inclined to search a topic online for a quick sound bite, this book is yet more evidence why books are still needed and, more importantly, still need to be read for better patient care." --Reviewed by Tariq M. Malik, MD (University of Chicago Pritzker School of Medicine)