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The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention.
A Review of the Cholinergic System and Therapeutic Approachesto Treat Brain Disorders.- Acetylcholine and Spontaneous Recognition Memory in Rodentsand Primates.- Endogenous Acetylcholine and Its Modulation of Cortical Microcircuitsto Enhance Cognition.- Cholinergic Signaling Dynamics and Cognitive Control of Attention.- Involvement of Nicotinic Receptors in Working Memory Function.- Nicotinic Receptors Underlying Nicotine Dependence: Evidence fromTransgenic Mouse Models.- Cholinergic Receptors and Addiction.- Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors.- An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism Spectrum Disorder.- Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment.
