Basic Radiotherapy Physics and Biology

David S. Chang, MD, MS is a Radiation Oncologist at the CHRISTUS St. Patrick Regional Cancer Center in Lake Charles, LA, USA.Foster D. Lasley, MD is a Radiation Oncologist at GenesisCare in Rogers, AK.Indra J. Das, PhD, FACR, FASTRO is a professor and vice chair at northwestern university Feinberg School of Medicine, Chicago.Marc S. Mendonca, PhD is a Professor of Radiation Oncology & Medical and Molecular Genetics, and Director of Radiation and Cancer Biology at Indiana University School of Medicine.Joseph R. Dynlacht, PhD is a Professor of Radiation Oncology & BIOCHEMISTRY AND MOLECULAR BIOLOGY at Indiana University School of Medicine.

• Part I: Radiation Therapy Physics.- Atomic and Nuclear Structure.- Radioactive Decay.- Properties and Production of Radiation.- Interactions of Electromagnetic Radiation with Matter.- Interactions of Particulate Radiation with Matter.- Quantification and Measurement of Dose.- Characteristics of Photon Beams.- Dosimetry of Photon Beams in Water.- Dosimetry of Photon Beams in a Patient.- Dosimetry of Electron Beams.- Physics and Dosimetry of Brachytherapy.- Advanced Treatment Planning for EBRT.- Linac Quality Assurance.- Radiation Protection and Safety.- Quality Management Program.- Special Topics: Hyperthermia and Computers.- MRI linac.- Proton Beam Radiotherapy.- Part II: Radiation Therapy Biology.- Molecular Biology and Signaling.- Cancer Genetic and Molecular Characteristics.- Molecular Mechanisms of DNA Damage and Repair.- Cell Death and Survival Assays.- Fractionated Radiation Survival Models.- Oxygen Effect, Relative Biological Effectiveness and Linear Energy Transfer.- Tumor Micro-environment.- Cell and Tissue Kinetics.- Acute Effects of Total Body Irradiation (TBI).- Normal Tissue Radiation Responses.- Therapeutic Ratio.- Combined Modality Therapy.- Biology of Brachytherapy, Particle Therapy, and Alternative Radiation Modalities.- Chemomodulation and Immunomodulation of Radiation In Vitro and In Vivo.- Hyperthermia.- Stochastic and deterministic Late Effects.- Radiation Effects in the Embryo and Fetus.- Appendix A: Glossary of Terms and Physical Constants.- Appendix B: List of Radionuclides for Radiotherapy and Imaging