José Jalife, M.D., F.A.C.C., F.H.R.S.Professor and Chairman of PharmacologyProfessor of Medicine and PediatricsDirector, Institute for Cardiovascular ResearchSUNY Upstate Medical UniversitySyracuse, NYMario Delmar, M.D., Ph.D., F.H.R.S.Professor of PharmacologyCo-Director, Institute for Cardiovascular ResearchSUNY Upstate Medical UniversitySyracuse, NY Justus Anumonwo, Ph.D.Assistant Professor of PharmacologyMember, Institute for Cardiovascular ResearchSUNY Upstate Medical UniversitySyracuse, NY Omer Berenfeld Jerome Kalifa

• Acknowledgments, vii Foreword to the Second Edition by Douglas P. Zipes, ixForeword to the First Edition by Douglas P. Zipes, xiIntroduction, 1Chapter 1 Bioelectricity, 7Chapter 2 Ion Channels, 43Chapter 3 Ion Channel Regulation, 72Chapter 4 Impulse Initiation and Propagation in Cardiac Muscle, 92Chapter 5 Rate Dependency of Discontinuous Propagation, 121Chapter 6 Basic Mechanisms of Cardiac Arrhythmias, 152Chapter 7 Rotors, Spirals, and Scroll Waves in the Heart, 191Chapter 8 Rotors and the Mechanisms of Atrial Fibrillation, 224Chapter 9 Molecular Mechanisms of Ventricular Fibrillation, 254Chapter 10 Inheritable Arrhythmogenic Diseases, 276Bibliography, 316Index, 335

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