Del 111 i serien Annals of the New York Academy of Sciences

Barriers and Channels Formed by Tight Junction Proteins II, Volume 1258

Häftad, Engelska, 2012

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Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins—the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)—can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia.NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on instutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Produktinformation

Utgivningsdatum2012-08-17
Mått178 x 255 x 9 mm
Vikt435 g
FormatHäftad
SpråkEngelska
SerieAnnals of the New York Academy of Sciences
Antal sidor191
FörlagJohn Wiley and Sons Ltd
ISBN9781573318921

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Cellbiologi inom Naturvetenskap och teknik

TNF-[alpha]-induced intestinal epithelial cell shedding : implications for intestinal barrier function / Alastair J.M. Watson and Kevin R. Hughes Tight junctions on the move : molecular mechanisms for epithelial barrier regulation / Le ShenHIV infection and the intestinal mucosal barrier / Hans-Jörg Epple and Martin ZeitzZonulin, regulation of tight junctions, and autoimmune diseases / Alessio FasanoMyosin light chain kinase : pulling the strings of epithelial tight junction function / Kevin E. Cunningham and Jerrold R. TurnerDefective tight junctions in refractory celiac disease / Michael Schumann [and others]Microbial butyrate and its role for barrier function in the gastrointestinal tract / Svenja Plöger [and others]SUMOylation of claudin-2 / Christina M. Van Itallie, Laura L. Mitic and James M. AndersonProof of concept for claudin-targeted drug development / Hidehiko Suzuki [and others]Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction / Yongjia Feng [and others]The protein C pathway in intestinal barrier function : challenging the hemostasis paradigm / Silvia D'Alessio, Marco Genua and Stefania VetranoAnalysis of absorption enhancers in epithelial cell models / Rita Rosenthal [and others]Calcium regulation of tight junction permeability / Markus Bleich, Qixian Shan and Nina HimmerkusEffects of quercetin studied in colonic HT-29/B6 cells and rat intestine in vitro / Maren Amasheh [and others]Claudin-based paracellular proton barrier in the stomach / Atsushi Tamura [and others]Regulation of epithelial proliferation by tight junction proteins / Attila E. Farkas, Christopher T. Capaldo and Asma NusratBarrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease / Åsa V. Keita and Johan D. SöderholmThe protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium / Caroline M. Weight and Simon R. CardingIon transport and barrier function are disturbed in microscopic colitis / Christian Barmeyer [and others]Enteropathogenic E. coli effectors EspG1/G2 disrupt tight junctions : new roles and mechanisms / Lila G. Glotfelty and Gail A. HechtAbnormal intestinal permeability in Crohn's disease pathogenesis / Christopher W. Teshima, Levinus A. Dieleman and Jon B. MeddingsA dynamic paracellular pathway serves diuresis in mosquito Malpighian tubules / Klaus W. BeyenbachImpaired paracellular ion transport in the loop of Henle causes familial hypomagnesemia with hypercalciuria and nephrocalcinosis / Lea Haisch and Martin KonradThe yin and yang of claudin-14 function in human diseases / Jianghui Hou