Christine Gleason, M.D. is an academic neonatologist and Professor Emeritus of Pediatrics at University of Washington and Seattle Children's Hospital. She recently retired from clinical practice and now devotes her time and effort to professional society leadership (Secretary-Treasurer of the American Pediatric Society; member of the Pediatric Policy Council); educational scholarship (Co-Editor of Avery's Diseases of the Newborn); Board certification (Medical Editor at the American Board of Pediatrics); and advisory/consulting activities (FDA Pediatric Advisory Committee; Data Safety & Monitoring Committee of the NIH's Maternal-Fetal Medicine Clinical Trials Network).

• P A R T IOverviewChapter 1 Neonatal and PerinatalEpidemiology, 1Chapter 2 Evaluation of TherapeuticRecommendations, DatabaseManagement, and InformationRetrieval, 10Chapter 3 Ethics, Data, and Policy inNewborn Intensive Care, 18Chapter 4 Global Neonatal Health, 23P A R T IIFetal DevelopmentChapter 5 Immunologic Basis of PlacentalFunction and Diseases: ThePlacenta, Fetal Membranes, andUmbilical Cord, 37Chapter 6 Abnormalities of FetalGrowth, 51Chapter 7 Multiple Gestations and AssistedReproductive Technology, 60Chapter 8 Nonimmune Hydrops, 67P A R T IIIMaternal Health Affecting NeonatalOutcomeChapter 9 Endocrine Disorders inPregnancy, 75Chapter 10 Maternal Medical Disorders ofFetal Significance: Seizure Disorders,Isoimmunization, Cancer,and Mental Health Disorders, 92Chapter 11 Hypertensive Complications ofPregnancy, 105Chapter 12 Perinatal Substance Abuse, 111P A R T IVLabor and DeliveryChapter 13 Antepartum Fetal Assessment, 129Chapter 14 Prematurity: Causes andPrevention, 140Chapter 15 Complicated Deliveries:Overview, 146Chapter 16 Obstetric Analgesia andAnesthesia, 159P A R T VGeneticsChapter 17 Impact of the Human GenomeProject on Neonatal Care, 173Chapter 18 Prenatal Genetic Diagnosis, 180Diana W. BianchiChapter 19 Evaluation of the DysmorphicInfant, 186Chapter 20 Specific Chromosome Disordersin Newborns, 196P A R T VIMetabolic and Endocrine Disordersof the NewbornChapter 21 Introduction to Metabolic andBiochemical Genetic Disease, 209CONTENTSxviii CONTENTSChapter 22 Inborn Errors of Carbohydrate,Ammonia, Amino Acid, andOrganic Acid Metabolism, 215Chapter 23 Lysosomal Storage, Peroxisomal,and Glycosylation Disordersand Smith-Lemli-Opitz Syndromein the Neonate, 239Chapter 24 Skeletal Dysplasias andConnective Tissue Disorders, 258P A R T VIICare of the Healthy NewbornChapter 25 Initial Evaluation: History andPhysical Examination of theNewborn, 277Chapter 26 Routine Newborn Care, 300Chapter 27 Newborn Screening, 316Chapter 28 Resuscitation in the DeliveryRoom, 328P A R T VIIICare of the High-Risk InfantChapter 29 Stabilization and Transportof the High-Risk Infant, 341Chapter 30 Temperature Regulation of thePremature Neonate, 357Chapter 31 Acid-Base, Fluid, and ElectrolyteManagement, 367Chapter 32 Care of the Extremely Low-Birthweight Infant, 390Chapter 33 Care of the Late PretermInfant, 405Chapter 34 Pharmacokinetics,Pharmacodynamics,and Pharmacogenetics, 417Chapter 35 Neonatal Pain and Stress:Assessment and Management, 429P A R T IXImmunology and InfectionsChapter 36 Immunology of the Fetusand Newborn, 445Chapter 37 Viral Infections of the Fetus andNewborn and Human Immunodeficiency VirusInfection During Pregnancy, 468Chapter 38 Toxoplasmosis, Syphilis, Malaria,and Tuberculosis, 513Chapter 39 Neonatal Bacterial Sepsis, 538Chapter 40 Health Care - Acquired Infectionsin the Nursery, 551Chapter 41 Fungal Infections in theNeonatal Intensive Care Unit, 565P A R T XRespiratory SystemChapter 42 Lung Development: Embryology,Growth, Maturation,and Developmental Biology, 571Maria Victoria Fraga ? Susan GuttentagChapter 43 Control of Breathing, 584Estelle B. Gauda ? Richard J. MartinChapter 44 Pulmonary Physiologyof the Newborn, 598Chapter 45 Principles of RespiratoryMonitoring and Therapy, 612Chapter 46 Respiratory Distressin the Preterm Infant, 633Chapter 47 Respiratory Failure in the TermNewborn, 647Chapter 48 Bronchopulmonary Dysplasia, 658Chapter 49 Surgical Disorders of the Chestand Airways, 672CONTENTS xixP A R T XICardiovascular SystemChapter 50 Embryology and Physiologyof the Cardiovascular System, 699Chapter 51 Cardiovascular Compromisein the Newborn Infant, 714Chapter 52 Persistent PulmonaryHypertension, 732Chapter 53 Fetal and NeonatalEchocardiography, 741Chapter 54 Patent Ductus Arteriosusin the Preterm Infant, 751Chapter 55 Congenital Heart Disease, 762Chapter 56 Arrhythmias in the Fetusand Newborn, 789Chapter 57 Neurodevelopmental Outcomesin Children with CongenitalHeart Disease, 801P A R T XIINeurologic SystemChapter 58 Developmental Physiology ofthe Central NervousSystem, 811Chapter 59 Neonatal Neuroimaging, 816Chapter 60 Congenital Malformationsof the Central NervousSystem, 844Chapter 61 Central Nervous System Injuryand Neuroprotection, 869Chapter 62 Neonatal NeuromuscularDisorders, 892Chapter 63 Neonatal Seizures, 901Chapter 64 Risk Assessment andNeurodevelopmentalOutcomes, 920P A R T XIIINutritionChapter 65 Breastfeeding, 937Chapter 66 Enteral Nutrition for theHigh-Risk Neonate, 952Chapter 67 Parenteral Nutrition, 963P A R T XIVGastrointestinal SystemChapter 68 Developmental Anatomyand Physiology of theGastrointestinal Tract, 973Chapter 69 Structural Anomalies of theGastrointestinal Tract, 979Chapter 70 Innate and Mucosal Immunity inthe Developing GastrointestinalTract: Relationship to Early andLater Disease, 994Chapter 71 Abdominal Wall Problems, 1007Chapter 72 The Developing IntestinalMicrobiome: Implicationsfor the Neonate, 1016Chapter 73 Necrotizing Enterocolitisand Short Bowel Syndrome, 1022Chapter 74 Disorders of the Liver, 1030P A R T XVHematologic System and Disordersof Bilirubin MetabolismChapter 75 Developmental Biology of theHematologic System, 1047Chapter 76 Hemostatic Disorders of theNewborn, 1056Chapter 77 Erythrocyte Disorders inInfancy, 1080CONTENTSChapter 78 Neonatal Leukocyte Physiologyand Disorders, 1108Chapter 79 Neonatal IndirectHyperbilirubinemia andKernicterus, 1123P A R T XVINeoplasiaChapter 80 Congenital MalignantDisorders, 1143P A R T XVIIRenal and Genitourinary SystemsChapter 81 Renal Morphogenesis andDevelopment of RenalFunction, 1165Chapter 82 Clinical Evaluation of Renal andUrinary Tract Disease, 1176Chapter 83 Developmental Abnormalities ofthe Kidneys, 1182Chapter 84 Developmental Abnormalities ofthe Genitourinary System, 1191Chapter 85 Acute Kidney Injury and ChronicKidney Disease, 1205Chapter 86 Glomerulonephropathiesand Disorders of TubularFunction, 1222Chapter 87 Urinary Tract Infections andVesicoureteral Reflux, 1228Chapter 88 Renal Vascular Disease in theNewborn, 1235P A R T XVIIIEndocrine DisordersChapter 89 Embryology, DevelopmentalBiology, and Anatomy of theEndocrine System, 1245Chapter 90 Disorders of Calcium andPhosphorus Metabolism, 1255Chapter 91 Disorders of the AdrenalGland, 1274Chapter 92 Ambiguous Genitalia in theNewborn, 1286Chapter 93 Disorders of the ThyroidGland, 1307Chapter 94 Disorders of CarbohydrateMetabolism, 1320P A R T XIXCraniofacial and OrthopedicConditionsChapter 95 CraniofacialMalformations, 1331Chapter 96 Common Neonatal OrthopedicAilments, 1351P A R T XXDermatologic ConditionsChapter 97 Newborn Skin: Developmentand Basic Concepts, 1363Chapter 98 Congenital and HereditaryDisorders of the Skin, 1373Chapter 99 Infections of the Skin, 1390Chapter 100 Common NewbornDermatoses, 1397Chapter 101 Cutaneous CongenitalDefects, 1406P A R T XXIThe EyeChapter 102 Disorders of the Eye, 1423

Christine Gleason, M.D. is an academic neonatologist and Professor Emeritus of Pediatrics at University of Washington and Seattle Children's Hospital. She recently retired from clinical practice and now devotes her time and effort to professional society leadership (Secretary-Treasurer of the American Pediatric Society; member of the Pediatric Policy Council); educational scholarship (Co-Editor of Avery's Diseases of the Newborn); Board certification (Medical Editor at the American Board of Pediatrics); and advisory/consulting activities (FDA Pediatric Advisory Committee; Data Safety & Monitoring Committee of the NIH's Maternal-Fetal Medicine Clinical Trials Network).

• P A R T IOverviewChapter 1 Neonatal and PerinatalEpidemiology, 1Chapter 2 Evaluation of TherapeuticRecommendations, DatabaseManagement, and InformationRetrieval, 10Chapter 3 Ethics, Data, and Policy inNewborn Intensive Care, 18Chapter 4 Global Neonatal Health, 23P A R T IIFetal DevelopmentChapter 5 Immunologic Basis of PlacentalFunction and Diseases: ThePlacenta, Fetal Membranes, andUmbilical Cord, 37Chapter 6 Abnormalities of FetalGrowth, 51Chapter 7 Multiple Gestations and AssistedReproductive Technology, 60Chapter 8 Nonimmune Hydrops, 67P A R T IIIMaternal Health Affecting NeonatalOutcomeChapter 9 Endocrine Disorders inPregnancy, 75Chapter 10 Maternal Medical Disorders ofFetal Significance: Seizure Disorders,Isoimmunization, Cancer,and Mental Health Disorders, 92Chapter 11 Hypertensive Complications ofPregnancy, 105Chapter 12 Perinatal Substance Abuse, 111P A R T IVLabor and DeliveryChapter 13 Antepartum Fetal Assessment, 129Chapter 14 Prematurity: Causes andPrevention, 140Chapter 15 Complicated Deliveries:Overview, 146Chapter 16 Obstetric Analgesia andAnesthesia, 159P A R T VGeneticsChapter 17 Impact of the Human GenomeProject on Neonatal Care, 173Chapter 18 Prenatal Genetic Diagnosis, 180Diana W. BianchiChapter 19 Evaluation of the DysmorphicInfant, 186Chapter 20 Specific Chromosome Disordersin Newborns, 196P A R T VIMetabolic and Endocrine Disordersof the NewbornChapter 21 Introduction to Metabolic andBiochemical Genetic Disease, 209CONTENTSxviii CONTENTSChapter 22 Inborn Errors of Carbohydrate,Ammonia, Amino Acid, andOrganic Acid Metabolism, 215Chapter 23 Lysosomal Storage, Peroxisomal,and Glycosylation Disordersand Smith-Lemli-Opitz Syndromein the Neonate, 239Chapter 24 Skeletal Dysplasias andConnective Tissue Disorders, 258P A R T VIICare of the Healthy NewbornChapter 25 Initial Evaluation: History andPhysical Examination of theNewborn, 277Chapter 26 Routine Newborn Care, 300Chapter 27 Newborn Screening, 316Chapter 28 Resuscitation in the DeliveryRoom, 328P A R T VIIICare of the High-Risk InfantChapter 29 Stabilization and Transportof the High-Risk Infant, 341Chapter 30 Temperature Regulation of thePremature Neonate, 357Chapter 31 Acid-Base, Fluid, and ElectrolyteManagement, 367Chapter 32 Care of the Extremely Low-Birthweight Infant, 390Chapter 33 Care of the Late PretermInfant, 405Chapter 34 Pharmacokinetics,Pharmacodynamics,and Pharmacogenetics, 417Chapter 35 Neonatal Pain and Stress:Assessment and Management, 429P A R T IXImmunology and InfectionsChapter 36 Immunology of the Fetusand Newborn, 445Chapter 37 Viral Infections of the Fetus andNewborn and Human Immunodeficiency VirusInfection During Pregnancy, 468Chapter 38 Toxoplasmosis, Syphilis, Malaria,and Tuberculosis, 513Chapter 39 Neonatal Bacterial Sepsis, 538Chapter 40 Health Care - Acquired Infectionsin the Nursery, 551Chapter 41 Fungal Infections in theNeonatal Intensive Care Unit, 565P A R T XRespiratory SystemChapter 42 Lung Development: Embryology,Growth, Maturation,and Developmental Biology, 571Maria Victoria Fraga ? Susan GuttentagChapter 43 Control of Breathing, 584Estelle B. Gauda ? Richard J. MartinChapter 44 Pulmonary Physiologyof the Newborn, 598Chapter 45 Principles of RespiratoryMonitoring and Therapy, 612Chapter 46 Respiratory Distressin the Preterm Infant, 633Chapter 47 Respiratory Failure in the TermNewborn, 647Chapter 48 Bronchopulmonary Dysplasia, 658Chapter 49 Surgical Disorders of the Chestand Airways, 672CONTENTS xixP A R T XICardiovascular SystemChapter 50 Embryology and Physiologyof the Cardiovascular System, 699Chapter 51 Cardiovascular Compromisein the Newborn Infant, 714Chapter 52 Persistent PulmonaryHypertension, 732Chapter 53 Fetal and NeonatalEchocardiography, 741Chapter 54 Patent Ductus Arteriosusin the Preterm Infant, 751Chapter 55 Congenital Heart Disease, 762Chapter 56 Arrhythmias in the Fetusand Newborn, 789Chapter 57 Neurodevelopmental Outcomesin Children with CongenitalHeart Disease, 801P A R T XIINeurologic SystemChapter 58 Developmental Physiology ofthe Central NervousSystem, 811Chapter 59 Neonatal Neuroimaging, 816Chapter 60 Congenital Malformationsof the Central NervousSystem, 844Chapter 61 Central Nervous System Injuryand Neuroprotection, 869Chapter 62 Neonatal NeuromuscularDisorders, 892Chapter 63 Neonatal Seizures, 901Chapter 64 Risk Assessment andNeurodevelopmentalOutcomes, 920P A R T XIIINutritionChapter 65 Breastfeeding, 937Chapter 66 Enteral Nutrition for theHigh-Risk Neonate, 952Chapter 67 Parenteral Nutrition, 963P A R T XIVGastrointestinal SystemChapter 68 Developmental Anatomyand Physiology of theGastrointestinal Tract, 973Chapter 69 Structural Anomalies of theGastrointestinal Tract, 979Chapter 70 Innate and Mucosal Immunity inthe Developing GastrointestinalTract: Relationship to Early andLater Disease, 994Chapter 71 Abdominal Wall Problems, 1007Chapter 72 The Developing IntestinalMicrobiome: Implicationsfor the Neonate, 1016Chapter 73 Necrotizing Enterocolitisand Short Bowel Syndrome, 1022Chapter 74 Disorders of the Liver, 1030P A R T XVHematologic System and Disordersof Bilirubin MetabolismChapter 75 Developmental Biology of theHematologic System, 1047Chapter 76 Hemostatic Disorders of theNewborn, 1056Chapter 77 Erythrocyte Disorders inInfancy, 1080CONTENTSChapter 78 Neonatal Leukocyte Physiologyand Disorders, 1108Chapter 79 Neonatal IndirectHyperbilirubinemia andKernicterus, 1123P A R T XVINeoplasiaChapter 80 Congenital MalignantDisorders, 1143P A R T XVIIRenal and Genitourinary SystemsChapter 81 Renal Morphogenesis andDevelopment of RenalFunction, 1165Chapter 82 Clinical Evaluation of Renal andUrinary Tract Disease, 1176Chapter 83 Developmental Abnormalities ofthe Kidneys, 1182Chapter 84 Developmental Abnormalities ofthe Genitourinary System, 1191Chapter 85 Acute Kidney Injury and ChronicKidney Disease, 1205Chapter 86 Glomerulonephropathiesand Disorders of TubularFunction, 1222Chapter 87 Urinary Tract Infections andVesicoureteral Reflux, 1228Chapter 88 Renal Vascular Disease in theNewborn, 1235P A R T XVIIIEndocrine DisordersChapter 89 Embryology, DevelopmentalBiology, and Anatomy of theEndocrine System, 1245Chapter 90 Disorders of Calcium andPhosphorus Metabolism, 1255Chapter 91 Disorders of the AdrenalGland, 1274Chapter 92 Ambiguous Genitalia in theNewborn, 1286Chapter 93 Disorders of the ThyroidGland, 1307Chapter 94 Disorders of CarbohydrateMetabolism, 1320P A R T XIXCraniofacial and OrthopedicConditionsChapter 95 CraniofacialMalformations, 1331Chapter 96 Common Neonatal OrthopedicAilments, 1351P A R T XXDermatologic ConditionsChapter 97 Newborn Skin: Developmentand Basic Concepts, 1363Chapter 98 Congenital and HereditaryDisorders of the Skin, 1373Chapter 99 Infections of the Skin, 1390Chapter 100 Common NewbornDermatoses, 1397Chapter 101 Cutaneous CongenitalDefects, 1406P A R T XXIThe EyeChapter 102 Disorders of the Eye, 1423

Christine Gleason, M.D. is an academic neonatologist and Professor Emeritus of Pediatrics at University of Washington and Seattle Children's Hospital. She recently retired from clinical practice and now devotes her time and effort to professional society leadership (Secretary-Treasurer of the American Pediatric Society; member of the Pediatric Policy Council); educational scholarship (Co-Editor of Avery's Diseases of the Newborn); Board certification (Medical Editor at the American Board of Pediatrics); and advisory/consulting activities (FDA Pediatric Advisory Committee; Data Safety & Monitoring Committee of the NIH's Maternal-Fetal Medicine Clinical Trials Network).

• P A R T IOverviewChapter 1 Neonatal and PerinatalEpidemiology, 1Chapter 2 Evaluation of TherapeuticRecommendations, DatabaseManagement, and InformationRetrieval, 10Chapter 3 Ethics, Data, and Policy inNewborn Intensive Care, 18Chapter 4 Global Neonatal Health, 23P A R T IIFetal DevelopmentChapter 5 Immunologic Basis of PlacentalFunction and Diseases: ThePlacenta, Fetal Membranes, andUmbilical Cord, 37Chapter 6 Abnormalities of FetalGrowth, 51Chapter 7 Multiple Gestations and AssistedReproductive Technology, 60Chapter 8 Nonimmune Hydrops, 67P A R T IIIMaternal Health Affecting NeonatalOutcomeChapter 9 Endocrine Disorders inPregnancy, 75Chapter 10 Maternal Medical Disorders ofFetal Significance: Seizure Disorders,Isoimmunization, Cancer,and Mental Health Disorders, 92Chapter 11 Hypertensive Complications ofPregnancy, 105Chapter 12 Perinatal Substance Abuse, 111P A R T IVLabor and DeliveryChapter 13 Antepartum Fetal Assessment, 129Chapter 14 Prematurity: Causes andPrevention, 140Chapter 15 Complicated Deliveries:Overview, 146Chapter 16 Obstetric Analgesia andAnesthesia, 159P A R T VGeneticsChapter 17 Impact of the Human GenomeProject on Neonatal Care, 173Chapter 18 Prenatal Genetic Diagnosis, 180Diana W. BianchiChapter 19 Evaluation of the DysmorphicInfant, 186Chapter 20 Specific Chromosome Disordersin Newborns, 196P A R T VIMetabolic and Endocrine Disordersof the NewbornChapter 21 Introduction to Metabolic andBiochemical Genetic Disease, 209CONTENTSxviii CONTENTSChapter 22 Inborn Errors of Carbohydrate,Ammonia, Amino Acid, andOrganic Acid Metabolism, 215Chapter 23 Lysosomal Storage, Peroxisomal,and Glycosylation Disordersand Smith-Lemli-Opitz Syndromein the Neonate, 239Chapter 24 Skeletal Dysplasias andConnective Tissue Disorders, 258P A R T VIICare of the Healthy NewbornChapter 25 Initial Evaluation: History andPhysical Examination of theNewborn, 277Chapter 26 Routine Newborn Care, 300Chapter 27 Newborn Screening, 316Chapter 28 Resuscitation in the DeliveryRoom, 328P A R T VIIICare of the High-Risk InfantChapter 29 Stabilization and Transportof the High-Risk Infant, 341Chapter 30 Temperature Regulation of thePremature Neonate, 357Chapter 31 Acid-Base, Fluid, and ElectrolyteManagement, 367Chapter 32 Care of the Extremely Low-Birthweight Infant, 390Chapter 33 Care of the Late PretermInfant, 405Chapter 34 Pharmacokinetics,Pharmacodynamics,and Pharmacogenetics, 417Chapter 35 Neonatal Pain and Stress:Assessment and Management, 429P A R T IXImmunology and InfectionsChapter 36 Immunology of the Fetusand Newborn, 445Chapter 37 Viral Infections of the Fetus andNewborn and Human Immunodeficiency VirusInfection During Pregnancy, 468Chapter 38 Toxoplasmosis, Syphilis, Malaria,and Tuberculosis, 513Chapter 39 Neonatal Bacterial Sepsis, 538Chapter 40 Health Care - Acquired Infectionsin the Nursery, 551Chapter 41 Fungal Infections in theNeonatal Intensive Care Unit, 565P A R T XRespiratory SystemChapter 42 Lung Development: Embryology,Growth, Maturation,and Developmental Biology, 571Maria Victoria Fraga ? Susan GuttentagChapter 43 Control of Breathing, 584Estelle B. Gauda ? Richard J. MartinChapter 44 Pulmonary Physiologyof the Newborn, 598Chapter 45 Principles of RespiratoryMonitoring and Therapy, 612Chapter 46 Respiratory Distressin the Preterm Infant, 633Chapter 47 Respiratory Failure in the TermNewborn, 647Chapter 48 Bronchopulmonary Dysplasia, 658Chapter 49 Surgical Disorders of the Chestand Airways, 672CONTENTS xixP A R T XICardiovascular SystemChapter 50 Embryology and Physiologyof the Cardiovascular System, 699Chapter 51 Cardiovascular Compromisein the Newborn Infant, 714Chapter 52 Persistent PulmonaryHypertension, 732Chapter 53 Fetal and NeonatalEchocardiography, 741Chapter 54 Patent Ductus Arteriosusin the Preterm Infant, 751Chapter 55 Congenital Heart Disease, 762Chapter 56 Arrhythmias in the Fetusand Newborn, 789Chapter 57 Neurodevelopmental Outcomesin Children with CongenitalHeart Disease, 801P A R T XIINeurologic SystemChapter 58 Developmental Physiology ofthe Central NervousSystem, 811Chapter 59 Neonatal Neuroimaging, 816Chapter 60 Congenital Malformationsof the Central NervousSystem, 844Chapter 61 Central Nervous System Injuryand Neuroprotection, 869Chapter 62 Neonatal NeuromuscularDisorders, 892Chapter 63 Neonatal Seizures, 901Chapter 64 Risk Assessment andNeurodevelopmentalOutcomes, 920P A R T XIIINutritionChapter 65 Breastfeeding, 937Chapter 66 Enteral Nutrition for theHigh-Risk Neonate, 952Chapter 67 Parenteral Nutrition, 963P A R T XIVGastrointestinal SystemChapter 68 Developmental Anatomyand Physiology of theGastrointestinal Tract, 973Chapter 69 Structural Anomalies of theGastrointestinal Tract, 979Chapter 70 Innate and Mucosal Immunity inthe Developing GastrointestinalTract: Relationship to Early andLater Disease, 994Chapter 71 Abdominal Wall Problems, 1007Chapter 72 The Developing IntestinalMicrobiome: Implicationsfor the Neonate, 1016Chapter 73 Necrotizing Enterocolitisand Short Bowel Syndrome, 1022Chapter 74 Disorders of the Liver, 1030P A R T XVHematologic System and Disordersof Bilirubin MetabolismChapter 75 Developmental Biology of theHematologic System, 1047Chapter 76 Hemostatic Disorders of theNewborn, 1056Chapter 77 Erythrocyte Disorders inInfancy, 1080CONTENTSChapter 78 Neonatal Leukocyte Physiologyand Disorders, 1108Chapter 79 Neonatal IndirectHyperbilirubinemia andKernicterus, 1123P A R T XVINeoplasiaChapter 80 Congenital MalignantDisorders, 1143P A R T XVIIRenal and Genitourinary SystemsChapter 81 Renal Morphogenesis andDevelopment of RenalFunction, 1165Chapter 82 Clinical Evaluation of Renal andUrinary Tract Disease, 1176Chapter 83 Developmental Abnormalities ofthe Kidneys, 1182Chapter 84 Developmental Abnormalities ofthe Genitourinary System, 1191Chapter 85 Acute Kidney Injury and ChronicKidney Disease, 1205Chapter 86 Glomerulonephropathiesand Disorders of TubularFunction, 1222Chapter 87 Urinary Tract Infections andVesicoureteral Reflux, 1228Chapter 88 Renal Vascular Disease in theNewborn, 1235P A R T XVIIIEndocrine DisordersChapter 89 Embryology, DevelopmentalBiology, and Anatomy of theEndocrine System, 1245Chapter 90 Disorders of Calcium andPhosphorus Metabolism, 1255Chapter 91 Disorders of the AdrenalGland, 1274Chapter 92 Ambiguous Genitalia in theNewborn, 1286Chapter 93 Disorders of the ThyroidGland, 1307Chapter 94 Disorders of CarbohydrateMetabolism, 1320P A R T XIXCraniofacial and OrthopedicConditionsChapter 95 CraniofacialMalformations, 1331Chapter 96 Common Neonatal OrthopedicAilments, 1351P A R T XXDermatologic ConditionsChapter 97 Newborn Skin: Developmentand Basic Concepts, 1363Chapter 98 Congenital and HereditaryDisorders of the Skin, 1373Chapter 99 Infections of the Skin, 1390Chapter 100 Common NewbornDermatoses, 1397Chapter 101 Cutaneous CongenitalDefects, 1406P A R T XXIThe EyeChapter 102 Disorders of the Eye, 1423