Autoimmune Liver Disease

JAMES NEUBERGER studied at Oxford and trained at the Liver Unit, Kings College Hospital, in London. He has researched and written about liver disease and liver transplantation for over 35 years, including editing five books and serving as the editor of Transplantation and associate editor of The Journal of Hepatology. He is currently a consultant physician in the Liver Unit, Queen Elizabeth Hospital, Birmingham, UK. GIDEON M. HIRSCHFIELD is a clinician-scientist and expert in autoimmune liver disease practice and science. His experience spans many years in transplant Hepatology in North America and the United Kingdom, including numerous published works. He currently has a practice at the University of Toronto, Ontario, Canada.

• Preface xvContributors xviiAbbreviations xxiIntroduction: The Paradigm and Paradox of Liver Autoimmunity 1M. Eric GershwinSection I Scientific Basis of Clinical Autoimmune Liver Diseases 31 Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree 5Marco Carbone and Mario Strazzabosco2 Concepts of Autoimmunity Relevant to Autoimmune Liver Diseases 21Isaiah G. Roepe and John M. Vierling3 Genetics and Risk of Autoimmune Liver Diseases 47George F. Mells4 Autoantibodies and Understanding of Autoimmune Liver Diseases 65Benedetta Terziroli Beretta-Piccoli, Giorgina Mieli-Vergani, and Diego Vergani5 Environmental Exposure and Risk in Autoimmune Liver Diseases 83Ying Qi Li and Andrew L. MasonSection II Autoimmune Liver Diseases and Their Clinical Correlation 1036 Autoimmune Hepatitis 105Aliya Gulamhusein and Patrick McKiernan7 Primary Biliary Cholangitis 123Alessio Gerussi and Marco Carbone8 Primary Sclerosing Cholangitis 143Mette Vesterhus, Benedetta Terziroli Beretta-Piccoli, Kirsten Muri Boberg, and Giorgina Mieli-Vergani9 IgG4-Related Liver and Biliary Disease 163Eleanor Barnes and Emma L. CulverSection III Specific Clinical Challenges 18110 Managing Acute and Chronic Seronegative Liver Disease 183Marcus C. Robertson and Peter C. Hayes11 Managing Pregnant Women with Autoimmune Liver Disease 201Eleni Theocharidou and Michael A. Heneghan12 Bone Health in Patients with Autoimmune Liver Diseases 219Albert Parés and Núria GuañabensSection IV Transplantation and Its Role in Autoimmune Liver Disease 23313 Recurrent Autoimmune Liver Disease and Its Impact on Clinical Practice 235Carlos Moctezuma-Velázquez and Aldo J. Montano-Loza14 Recurrent Autoimmune Liver Disease and its Scientific Significance 247Atsushi Tanaka, Patrick S.C. Leung, and M. Eric GershwinSection V Controversies in Autoimmune Liver Diseases 26315 Making Sense of Overlap and Crossover Syndromes 265Olivier Chazouillères16 The Role of Extrahepatic Autoimmunity in Autoimmune Liver Disease 277Ewa Wunsch and Piotr Milkiewicz17 Symptoms, Chronic Disease, and Patient Management 289David JonesReferences 300Index 301